Article

Risk of coronary heart disease in patients with cancer: a nationwide follow-up study from Sweden.

Center for Primary Health Care Research, Lund University/Region Skåne, Clinical Research Centre, Floor 11, Building 28, Entrance 72, Skåne University Hospital, 205 02 Malmö, Sweden.
European journal of cancer (Oxford, England: 1990) (impact factor: 4.12). 01/2012; 48(1):121-8. DOI:10.1016/j.ejca.2011.09.015 pp.121-8
Source: PubMed

ABSTRACT Risk of coronary heart disease (CHD) in cancer patients has not been thoroughly investigated. The aim of the present study was to examine whether there is an association between cancer and first hospitalisation for CHD.
All individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for CHD. The reference population was the total population of Sweden without cancer. Standardised incidence ratios (SIRs) for CHD were calculated.
The overall CHD risk during the first 6 months after diagnosis of cancer was 1.70 (95% confidence interval (95% CI) 1.66-1.75). For 26 of the 34 cancers studied, the risk of CHD was increased during the first 6 months after diagnosis of cancer. The overall CHD risk decreased rapidly, but remained slightly elevated, even 10+years after diagnosis of cancer (SIR 1.07; 95% CI 1.04-1.11). The cancer sites/types for which risk of CHD was highest during the first 6 months were small intestine (SIR 2.88; 95% CI 2.02-3.99), leukaemia (SIR 2.84; 95% CI 2.37-3.37), kidney (SIR 2.65; 95% CI 2.30-3.04), lung (SIR 2.56; 95% CI 2.35-2.80) and liver (SIR 2.28; 95% CI 1.91-2.71). Metastases were associated with an increased risk of CHD (SIR 1.46; 95% CI 1.28-1.65).
Most cancers were associated with an increased risk of CHD during the first 6 months after diagnosis. CHD risk was related to the presence of metastates. Cancer patients may need a more aggressive treatment of classical CHD risk factors.

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Keywords

34 cancers
 
95% confidence interval
 
aggressive treatment
 
Cancer patients
 
cancer sites/types
 
cancers
 
CHD
 
CHD risk
 
classical CHD risk factors
 
coronary heart disease
 
first 6 months
 
first hospitalisation
 
increased risk
 
leukaemia
 
metastates
 
reference population
 
Standardised incidence ratios
 
Sweden
 
total population
 

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