Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea

Department of Pediatrics, Lokmanya Tilak Municipal General Hospital and Medical College, Sion, Mumbai - 400 022, India.
Indian Journal of Pharmacology (Impact Factor: 0.69). 09/2011; 43(5):601-2. DOI: 10.4103/0253-7613.84982
Source: PubMed


Tetrabenazine (TBZ) is widely used to treat hyperkinetic movement disorders in adults; however, published experience with the drug in children is limited. Common side effects of TBZ include drowsiness, sedation, weakness, Parkinsonism, depression, and acute akathisia, all of which are reversible with decreased doses. We report here a 7-year-old girl with rheumatic chorea who developed acute akinesia of all four limbs and dysarthria due to TBZ therapy. Withdrawal of the drug led to rapid improvement within 18 hours.

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