Survivin expression and its potential clinical significance in gastrointestinal stromal sarcoma

Gazi University Medical Faculty, Department Of Medical Oncology, Ankara, Turkey.
International immunopharmacology (Impact Factor: 2.47). 12/2011; 11(12):2227-31. DOI: 10.1016/j.intimp.2011.10.005
Source: PubMed


This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in gastrointestinal stromal sarcoma (GIST). Twenty patients (12 males and 8 females) ranging in age from 25 to 72, with a median age of 53 were evaluated. Failure of TKI treatment was higher in the survivin-positive group (p=0.06). The rate of metastasis was significantly higher in the survivin positive group vs. the negative group (80% vs. 30%, p=0.18). The median overall survival (OS) time was 114 (range 29-199)months, and the median disease-free survival (DFS) time was 88 (range 40-135) months. The median progression-free survival (PFS) time was 40 (range 24-55) months. Further, a comparison of patients with survivin positive versus negative tumors, revealed no significant difference for OS, DFS, and PFS (p=0.45, p=0.19, p=0.55, respectively), number of mitoses in 50 HPF (p=0.14), and tumor size (p=0.94). In conclusion, survivin was highly expressed in GISTs, although we found no correlation between survivin expression and PFS, DFS and OS, survivin may be a predictive marker in GISTs for disease progression. We believe that additional studies are warranted to determine the clinical significance of survivin expression as a prognostic or predictive marker in patients with GIST.

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Available from: Mustafa Benekli, Jul 27, 2014
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    • "Furthermore, increased levels of survivin are associated with a poor prognosis in numerous tumors [14]–[18], although some reports indicate that an elevated expression of survivin splice variants may represent a favorable prognostic marker in some cancers [19]. High survivin mRNA and protein levels seem to be significantly correlated with a poor prognosis in sarcomas, although there are few studies focusing on specific sarcomatous subtypes, sometimes with divergent results [20], [21]. Recent studies have suggested that BIRC5/SURVIVIN may represent a potential candidate gene associated with an unfavorable prognosis in MPNST in adult patients [10], [11]. "
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