Article

Small GTPase regulation of GPCR anterograde trafficking.

Institute of Respiratory Diseases, Second Affiliated Hospital of the Third Military Medical University, Chongqing 400037, China.
Trends in Pharmacological Sciences (impact factor: 10.93). 01/2012; 33(1):28-34. DOI:10.1016/j.tips.2011.09.002 pp.28-34
Source: PubMed

ABSTRACT The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis and recycling. By contrast, the molecular mechanisms underlying anterograde transport of newly synthesized GPCRs from the endoplasmic reticulum (ER) to the cell surface have only now begun to be revealed. In this review we discuss current advances in understanding the role of Ras-like GTPases, specifically the Rab and Sar1/ARF subfamilies, in regulating cell-surface transport of GPCRs en route from the ER and the Golgi.

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Keywords

anterograde transport
 
cell surface
 
current advances
 
endocytosis
 
functional destinations
 
GPCRs
 
GPCRs en route
 
heterotrimeric G protein-coupled receptors
 
intracellular trafficking
 
molecular mechanisms
 
physiological functions
 
Ras-like GTPases
 
regulating cell-surface transport
 
Sar1/ARF subfamilies
 
synthesized GPCRs
 

Guansong Wang