Time trends in testicular cancer in Croatia 1983-2007: Rapid increases in incidence, no declines in mortality
Laboratory for Epigenetics and Molecular Medicine, Department of Medical Biology, University of Zagreb Medical School, Zagreb, Croatia.Cancer epidemiology 02/2012; 36(1):11-5. DOI: 10.1016/j.canep.2011.09.010
Testicular cancer, although a rare malignancy, represents the most common cancer in young male populations of Western origin. While increasing incidence trends of testicular cancer have been reported, mortality is declining in many high-resource settings. Using national data from the Croatian National Cancer Registry for the period 1983-2007, time trends were analysed by joinpoint regression and Age-Period-Cohort models. The present study is the first to analyse the testicular cancer trends in the Croatian population. Over the 25-year period, a mean number of 89 incident cases and 13 deaths were reported annually. The observed mean annual increases in age-standardised rates were 7.0% for incidence and 1.6% for mortality, with no abrupt linear changes (joinpoints) identified. The incidence rates of testicular cancer incidence have been steeply increasing in successive cohorts born since the mid-1930s. The rapid rise in testicular cancer incidence in the Croatian population appears to be one of the highest rates of increase recorded in Europe and worldwide. The lack of decline in the mortality rates over time, while based on relatively few deaths, highlights a need for improvements in diagnostics and management of therapy in Croatia in order to improve the survival and quality-of-life of testicular cancer patients.
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- "The remaining 1% of TGCTs are spermatocytic seminomas which have a median age at diagnosis of 54 years and are etiologically dissimilar to other TGCTs. Testicular cancer rates in Northern European and North American countries have been rising over time with increases across successive birth cohorts reported for many of these countries (Bray et al., 2006; Sincic et al., 2012). In contrast, rates in other countries have been evaluated less frequently. "
ABSTRACT: Incidence rates of testicular cancer in Northern European and North American countries have been widely reported, whereas rates in other populations, such as Eastern Europe, Central/South America, Asia, and Africa, have been less frequently evaluated. We examined testicular cancer incidence rates overall and by histologic type by calendar time and birth cohort for selected global populations 1973–2007. Age-standardized incidence rates over succeeding 5-year periods were calculated from volumes 4–9 of Cancer Incidence in Five Continents electronic database (CI5plus) and the newly released CI5X (volume 10) database. Annual percent change over the 35-year period was calculated using weighted least squares regression. Age-period-cohort analyses were performed and observed rates and fitted rate ratios presented by birth cohort. Incidence rates of testicular cancer increased between 1973–1977 and 2003–2007 in most populations evaluated worldwide. Of note, incidence rates in Eastern European countries rose rapidly and approached rates in Northern European countries. Rates in Central and South America also increased and are now intermediate to the high rates among men of European ancestry and low rates among men of Asian or African descent. Some heterogeneity in the trends in seminoma and nonseminoma were observed in Denmark, the United Kingdom, and among US whites, particularly in recent generations, with rapid and uniform increases in the incidence of both histologic types in Slovakia. Reasons for the rising incidence rates among European and American populations remain unexplained; however, changing distributions in the prevalence of risk factors for testicular cancer cannot be ruled out.Andrology 10/2014; 3(1). DOI:10.1111/andr.293 · 2.30 Impact Factor
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- "Breast and testicular cancers affect a substantial and increasing proportion of the global population. The early treatment of these cancers impacts on the invasiveness of treatment, patient quality of life and survival rates, emphasizing the importance of timely cancer detection. "
ABSTRACT: Breast and testicular cancers affect a substantial and increasing proportion of the global population. Self-examination encourages early detection and treatment of these cancers, which positively impacts on patient quality of life and survival. The present study investigated the role of body esteem in breast and testicular self-examination. Men (N = 60) and women (N = 90) recruited from a British University completed the body esteem scale and either the testicular self-examination or breast self-examination questionnaire. Logistic regression models revealed that body esteem predicted women's intention to engage in breast self-examination. Women with higher levels of sexual attractiveness and those with lower levels of weight concern were more likely to report that they would regularly self-examine in the future. Body esteem did not however, distinguish between those women that did or did not currently self-examine or predict men's current or intended testicular self-examination. The findings have implications for the promotion of self-examination and highlight an emerging area of preventive health research.International journal of preventive medicine 06/2013; 4(6):684-9.
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ABSTRACT: The aim of this study was to establish three dimension high frequency ultrasound computed tomography (HFUCT) for detecting the testicular tumor in vitro. Currently, the UCT has been applied for diagnosing the breast cancer for females. This study is the first report for applying this modality for testicular tumor applications. Experiments were carried out by artificial testicular tumor from rat. Two 25 MHz transducers were used in this research. The transmitting transducer and receiving transducer were both fitted on the three-axes step motor platform by two brackets, and the testicle was fixed on a rotational stage which was controlled by a rotating motor. The projection data of UCT were obtained by measuring the ultrasonic attenuation. A filtered backprojection algorithm was used to reconstruct the HFUCT images. In the results of healthy testicle, the transmission attenuation HFUCT image and the B-mode imaging both showed that the testicular tissue had a homogeneous property because the distribution of ultrasonic attenuation seems uniform within whole testis. In the results of testicular tumor samples, it was difficult to detect the tumor by using B-mode image, however, the size and location of tumor was observed clearly by the HFUCT image. Moreover, the three dimensional HFUCT image was reconstructed in this study, and the volume of tumor can be measured accordingly.Ultrasonics Symposium (IUS), 2012 IEEE International; 01/2012
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