Time trends in testicular cancer in Croatia 1983-2007: Rapid increases in incidence, no declines in mortality
ABSTRACT Testicular cancer, although a rare malignancy, represents the most common cancer in young male populations of Western origin. While increasing incidence trends of testicular cancer have been reported, mortality is declining in many high-resource settings. Using national data from the Croatian National Cancer Registry for the period 1983-2007, time trends were analysed by joinpoint regression and Age-Period-Cohort models. The present study is the first to analyse the testicular cancer trends in the Croatian population. Over the 25-year period, a mean number of 89 incident cases and 13 deaths were reported annually. The observed mean annual increases in age-standardised rates were 7.0% for incidence and 1.6% for mortality, with no abrupt linear changes (joinpoints) identified. The incidence rates of testicular cancer incidence have been steeply increasing in successive cohorts born since the mid-1930s. The rapid rise in testicular cancer incidence in the Croatian population appears to be one of the highest rates of increase recorded in Europe and worldwide. The lack of decline in the mortality rates over time, while based on relatively few deaths, highlights a need for improvements in diagnostics and management of therapy in Croatia in order to improve the survival and quality-of-life of testicular cancer patients.
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- "Breast and testicular cancers affect a substantial and increasing proportion of the global population. The early treatment of these cancers impacts on the invasiveness of treatment, patient quality of life and survival rates, emphasizing the importance of timely cancer detection. "
ABSTRACT: Breast and testicular cancers affect a substantial and increasing proportion of the global population. Self-examination encourages early detection and treatment of these cancers, which positively impacts on patient quality of life and survival. The present study investigated the role of body esteem in breast and testicular self-examination. Men (N = 60) and women (N = 90) recruited from a British University completed the body esteem scale and either the testicular self-examination or breast self-examination questionnaire. Logistic regression models revealed that body esteem predicted women's intention to engage in breast self-examination. Women with higher levels of sexual attractiveness and those with lower levels of weight concern were more likely to report that they would regularly self-examine in the future. Body esteem did not however, distinguish between those women that did or did not currently self-examine or predict men's current or intended testicular self-examination. The findings have implications for the promotion of self-examination and highlight an emerging area of preventive health research.International journal of preventive medicine 06/2013; 4(6):684-9.
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ABSTRACT: The aim of this study was to establish three dimension high frequency ultrasound computed tomography (HFUCT) for detecting the testicular tumor in vitro. Currently, the UCT has been applied for diagnosing the breast cancer for females. This study is the first report for applying this modality for testicular tumor applications. Experiments were carried out by artificial testicular tumor from rat. Two 25 MHz transducers were used in this research. The transmitting transducer and receiving transducer were both fitted on the three-axes step motor platform by two brackets, and the testicle was fixed on a rotational stage which was controlled by a rotating motor. The projection data of UCT were obtained by measuring the ultrasonic attenuation. A filtered backprojection algorithm was used to reconstruct the HFUCT images. In the results of healthy testicle, the transmission attenuation HFUCT image and the B-mode imaging both showed that the testicular tissue had a homogeneous property because the distribution of ultrasonic attenuation seems uniform within whole testis. In the results of testicular tumor samples, it was difficult to detect the tumor by using B-mode image, however, the size and location of tumor was observed clearly by the HFUCT image. Moreover, the three dimensional HFUCT image was reconstructed in this study, and the volume of tumor can be measured accordingly.Ultrasonics Symposium (IUS), 2012 IEEE International; 01/2012
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ABSTRACT: The current working model of type II testicular germ cell tumor (TGCT) pathogenesis states that carcinoma in situ arises during embryogenesis, is a necessary precursor, and always progresses to cancer. An implicit condition of this model is that only in utero exposures affect the development of TGCT in later life. In an age-period-cohort analysis, this working model contends an absence of calendar period deviations. We tested this contention using data from the SEER registries of the United States. We assessed age-period-cohort models of TGCTs, seminomas, and nonseminomas for the period 1973-2008. Analyses were restricted to whites diagnosed at ages 15-74 years. We tested whether calendar period deviations were significant in TGCT incidence trends adjusted for age deviations and cohort effects. This analysis included 32,250 TGCTs (18,475 seminomas and 13,775 nonseminomas). Seminoma incidence trends have increased with an average annual percentage change in log-linear rates (net drift) of 1.25 %, relative to just 0.14 % for nonseminoma. In more recent time periods, TGCT incidence trends have plateaued and then undergone a slight decrease. Calendar period deviations were highly statistically significant in models of TGCT (p = 1.24(-9)) and seminoma (p = 3.99(-14)), after adjustment for age deviations and cohort effects; results for nonseminoma (p = 0.02) indicated that the effects of calendar period were much more muted. Calendar period deviations play a significant role in incidence trends of TGCT, which indicates that postnatal exposures are etiologically relevant.Cancer Causes and Control 07/2012; 23(10):1593-8. DOI:10.1007/s10552-012-0036-5 · 2.74 Impact Factor