Efficacy of a Novel Light-Activated Antimicrobial Coating for Disinfecting Hospital Surfaces

Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK.
Infection Control and Hospital Epidemiology (Impact Factor: 4.02). 11/2011; 32(11):1130-2. DOI: 10.1086/662377
Source: PubMed

ABSTRACT Silicone polymers containing the light-activated antimicrobial agent methylene blue with or without gold nanoparticles were evaluated for their ability to reduce the microbial load on surfaces in a clinical environment. When irradiated with white light, polymers containing nanogold were more effective in this respect than those containing only methylene blue.

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    ABSTRACT: Emerging technologies in antimicrobial coatings can help improve the quality and safety of our food supply. The goal of this review is to survey the major classes of antimicrobial agents explored for use in coatings and to describe the principles behind coating processes. Technologies from a range of fields, including biomedical and textiles research, as well as current applications in food contact materials, are addressed, and the technical hurdles that must be overcome to enable commercial adaptation to food processing equipment are critically evaluated. Expected final online publication date for the Annual Review of Food Science and Technology Volume 6 is February 28, 2015. Please see for revised estimates.
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    ABSTRACT: Aim of this study was to evaluate the reduction on Intensive Care Unit (ICU) microbial flora after the antimicrobial copper alloy (Cu+) implementation as well as the effect on financial – epidemiological operation parameters. Methods Medical, epidemiological and financial data into two time periods, before and after the implementation of copper (Cu 63 % – Zn 37 %, Low Lead) were recorded and analyzed in a General ICU. The evaluated parameters were: the importance of patients’ admission (Acute Physiology and Chronic Health Evaluation – APACHE II and Simplified Acute Physiology Score – SAPS), microbial flora’s record in the ICU before and after the implementation of Cu+ as well as the impact on epidemiological and ICU’s operation financial parameters.Results During December 2010 and March 2011 and respectively during December 2011 andMarch 2012 comparative results showed statistically significant reduction on the microbial flora (CFU/ml) by 95 % and the use of antimicrobial medicine (per day per patient) by 30 % (p¼0.014) as well as patients hospitalization time and cost. Conclusions The innovative implementation of antimicrobial copper in ICUs contributed to their microbial flora significant reduction and antimicrobial drugs use reduction with the apparent positive effect (decrease) in both patients’ hospitalization time and cost. Under the present circumstances of economic crisis, survey results are of highest importance and value.
    Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections, 1st edited by Gadi Borkow, 10/2014: chapter Economics of Using Biocidal Surfaces: pages 10; Springer (, ISBN: ISBN 978-3-319-08056-7 ISBN 978-3-319-08057-4 (eBook)


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