Chronic Disease and Hospitalisation For Pandemic (H1N1) 2009 Influenza in Indigenous and Non-Indigenous Western Australians
Indigenous and non-indigenous Western Australians with pandemic (H1N1) 2009 influenza (pH1N1) infection were compared for risk factors, influenza vaccination history, symptoms, use of antiviral medications, and hospitalisation. Data were collected systematically on 856 notified cases with laboratory confirmed pH1N1 infection during the first 10 weeks of pH1N1 virus transmission in Western Australia in 2009. Indigenous people with pH1N1 were approximately 3 times more likely to be hospitalised and were more likely to have a range of underlying medical conditions and be smokers, compared with non-Indigenous cases. Age (P < 0.001) and the presence of two or more co-morbidities (P < 0.001) were independent predictors of hospitalisation, while Indigenous status was not, indicating that higher pH1N1 hospitalisation rates in Indigenous Australians during the 2009 winter season were attributable to the higher prevalence of underlying chronic disease. These results underscore the need to ensure that influenza vaccination is delivered as widely as possible among those with chronic health conditions.
Available from: Robin Gilmour
- "In 2009, it was recognised that Indigenous people around the world experienced a greater risk of infection with the pandemic influenza virus and more severe outcomes
[28-30] although a Canadian study found no increased risk of intensive care admission or death among the Canadian Aboriginal populations
. A more recent study of Australian Aboriginal and Torres Strait Islander people found that a younger age distribution and a higher prevalence of underlying chronic conditions are a possible explanation for the apparent increased risk of influenza-related hospitalisation
. Improvements in the recording of Aboriginal status in hospitalisation data in NSW could affect the comparability of rates over time. "
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In Australia, the 2009 epidemic of influenza A(H1N1)pdm09 resulted in increased admissions to intensive care. The annual contribution of influenza to use of intensive care is difficult to estimate, as many people with influenza present without a classic influenza syndrome and laboratory testing may not be performed. We used a population-based approach to estimate and compare the impact of recent epidemics of seasonal and pandemic influenza.
For 2007 to 2010, time series describing health outcomes in various population groups were prepared from a database of all intensive care unit (ICU) admissions in the state of New South Wales, Australia. The Serfling approach, a time series method, was used to estimate seasonal patterns in health outcomes in the absence of influenza epidemics. The contribution of influenza was estimated by subtracting expected seasonal use from observed use during each epidemic period.
The estimated excess rate of influenza-associated respiratory ICU admissions per 100,000 inhabitants was more than three times higher in 2007 (2.6/100,000, 95% CI 2.0 to 3.1) than the pandemic year, 2009 (0.76/100,000, 95% CI 0.04 to 1.48). In 2009, the highest excess respiratory ICU admission rate was in 17 to 64 year olds (2.9/100,000, 95% CI 2.2 to 3.6), while in 2007, the highest excess rate was in those aged 65 years or older (9.5/100,000, 95% CI 6.2 to 12.8). In 2009, the excess rate was 17/100,000 (95% CI 14 to 20) in Aboriginal people and 14/100,000 (95% CI 13 to 16) in pregnant women.
While influenza was diagnosed more frequently and peak use of intensive care was higher during the epidemic of pandemic influenza in 2009, overall excess admissions to intensive care for respiratory illness was much greater during the influenza season in 2007. Thus, the impact of seasonal influenza on intensive care use may have previously been under-recognised. In 2009, high ICU use among young to middle aged adults was offset by relatively low use among older adults, and Aboriginal people and pregnant women were substantially over-represented in ICUs. Greater emphasis on prevention of serious illness in Aboriginal people and pregnant women should be a priority in pandemic planning.
BMC Public Health 10/2012; 12(1):869. DOI:10.1186/1471-2458-12-869 · 2.26 Impact Factor
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ABSTRACT: Analyses of mortality in Alaska and Labrador during the 1918 influenza pandemic indicate that influenza itself was only one of several factors influencing mortality in different communities. We discuss the added impact of exposure to influenza prior to the major waves of the pandemic in 1918 and cocirculation of other acute infectious diseases, including pneumonia, smallpox, and measles; chronic conditions such as nutritional deficiencies and tuberculosis; and social and cultural factors such as the economic climate, ethnicity, official responses, and access to health care. The emphasis is on potential explanations for differential mortality in these regions and on how the experiences of Labradoreans and Alaskans can help to inform us about the multitude of interrelated factors influencing modern health issues.
11/2012; 36(2). DOI:10.1111/napa.12011
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ABSTRACT: The 2009 H1N1 influenza pandemic posed challenges for governments worldwide. Strategies designed to limit community transmission, such as antiviral deployment, were largely ineffective due to both feasibility constraints and the generally mild nature of disease, resulting in incomplete case ascertainment. Reviews of national pandemic plans have identified pandemic impact, primarily linked to measures of transmissibility and severity, as a key concept to incorporate into the next generation of plans. While an assessment of impact provides the rationale under which interventions may be warranted, it does not directly provide an assessment on whether particular interventions may be effective. Such considerations motivate our introduction of the concept of pandemic controllability. For case-targeted interventions, such as antiviral treatment and post-exposure prophylaxis, we identify the visibility and transmissibility of a pandemic as the key drivers of controllability. Taking a case-study approach, we suggest that high-impact pandemics, for which control is most desirable, are likely uncontrollable with case-targeted interventions. Strategies that do not rely on the identification of cases may prove relatively more effective. By introducing a pragmatic framework for relating the assessment of impact to the ability to mitigate an epidemic (controllability), we hope to address a present omission identified in pandemic response plans.
Journal of Public Health 06/2013; 36(1). DOI:10.1093/pubmed/fdt058 · 2.04 Impact Factor
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