Article

[Chemical proteomics and discovery of drug targets].

Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Yao xue xue bao = Acta pharmaceutica Sinica 08/2011; 46(8):877-82. pp.877-82
Source: PubMed

ABSTRACT Medical community and pharmaceutical companies are currently facing a dire need for discovery and identification of new druggable targets. However, the discovery of small-molecule target is an important and arduous task for the biological and medical scientists. To overcome the bottlenecks for target validation, many new approaches are being developed, such as chemical proteomics. As a part of proteomics approaches, chemical proteomics employs small-molecule compounds that can specifically interact with the target protein to interfere with and detect proteomics. Therefore, new target identification, drug discovery and research on multi-target-directed drugs will all be benefited from the further advances in chemical proteomics approaches. Chemical proteomics has the potential to greatly enhance the efficiency of the drug discovery process.

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Keywords

arduous task
 
biological
 
chemical proteomics
 
chemical proteomics approaches
 
drug discovery process
 
Medical community
 
medical scientists
 
multi-target-directed drugs
 
new approaches
 
new druggable targets
 
new target identification
 
proteomics
 
proteomics approaches
 
small-molecule target
 
target protein
 
target validation
 

Hong-Qin Yang