Vitamin D and calcium levels in Ugandan adults with human immunodeficiency virus and tuberculosis

Mbarara University of Science and Technology/Teaching Hospital, Mbarara, Uganda.
The International Journal of Tuberculosis and Lung Disease (Impact Factor: 2.32). 11/2011; 15(11):1522-7, i. DOI: 10.5588/ijtld.10.0701
Source: PubMed


Vitamin D increases cathelicidin production, and might alter mortality due to tuberculosis (TB) in human immunodeficiency virus (HIV) coinfection. However, due to abundant sun exposure, vita min D levels might be excellent among Ugandans with HIV and TB.
We measured 25(OH)D and calcium levels in 50 HIV-negative, 50 HIV-infected and 50 TB-HIV coinfected Ugandan adults.
Mean ± standard deviation 25(OH)D levels were 26 ± 7 ng/ml in HIV-negative, 28 ± 11 ng/ml in HIV-infected and 24 ± 11 ng/ml in TB-HIV co-infected adults (P > 0.05 all comparisons). Vitamin D deficiency (< 12 ng/ml) was present in 10% of the HIV-infected subjects, 12% of the TB-HIV co-infected and none of the healthy controls (P = 0.03 for healthy vs. TB, P > 0.05 for other comparisons); 20% of the healthy controls, 22% of the HIV-positive and 38% of the TB-HIV co-infected subjects (P = 0.047 for healthy vs. TB, P > 0.05 for other comparisons) had suboptimal vitamin D levels (< 20 ng/ml). No participant had hypercalcemia. Serum 25(OH)D levels correlated positively with body mass index (r = 0.22, P = 0.03) and serum calcium levels (r = 0.18, P = 0.03).
Ugandan HIV-infected adults with and without TB commonly had suboptimal vitamin D levels. Clinical trials are needed to evaluate the effect of vitamin D on health outcomes in HIV-infected patients with low vitamin D levels.

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    • "Our finding of VDD-associated slower CD4þT- cell recovery is inconsistent with a previously reported lack of association between vitamin-D and CD4þT-cell recovery among HIV-infected African adults [5] [17], and with a longitudinal study of an ethnically diverse sample of HIV-positive patients from The Netherlands [21]. Similarly, our study findings do not support the results from one longitudinal study [21] and two cross-sectional studies that found no association between VDD and CD4þT- cell levels in HIV-infected adults from Uganda [17] and the United States [19]. The exact reason for this divergence in resultsdparticularly for the prospective studies including African Fig. 2. Age variation in absolute CD4þT-cell recovery post highly active antiretroviral therapy initiation. "
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    ABSTRACT: Background & aims: We implemented a prospective study among human immunodeficiency virus (HIV)-positive adults to examine the association between vitamin-D deficiency (VDD) and insufficiency (VDI) vs sufficiency (VDS) and CD4+T-cell improvement over 18 months of highly active antiretroviral therapy (HAART). Methods: We used data from a randomized placebo-controlled micronutrient trial with 25-hydroxy vitamin-D (25(OH)D) measured at enrollment in 398 adults. CD4+T-cell count was measured repeatedly at months 0, 3, 6, 12 and 18. Linear mixed models quantified the vitamin-D-related differences in CD4+T-cell count and associated 99% confidence intervals at baseline and respective follow-up intervals. Results: At baseline 23%, 60% and 17% of participants were VDS, VDI and VDD, respectively. Absolute CD4+T- cell counts recovered during follow-up were persistently lower for baseline VDD and VDI relative to VDS participants. The greatest deficit in absolute CD4+T-cells recovered occurred in VDD vs VDS participants with estimates ranging from a minimum deficit of 26 cells/μl (99% CI: -77, 26) to a maximum deficit of 65 cells/μl (99% CI: -125, -5.5) during follow-up. This VDD-associated lower absolute CD4+T-cell gain was strongest among patients 35 years old or younger and among participants with a baseline body mass index of less than 25 kg/m(2). Conclusions: VDD is associated with lower absolute CD4+T-cell count recovery in HIV-positive patients on HAART. Vitamin-D supplementation may improve CD4+T-cell recovery during HAART. However, future intervention studies are needed to definitively evaluate the effectiveness of this vitamin as an adjunct therapy during HAART.
    Clinical nutrition (Edinburgh, Scotland) 09/2015; DOI:10.1016/j.clnu.2015.08.007 · 4.48 Impact Factor
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    • "This demonstrates that vitamin D deficiency is highly prevalent among admitted adult TB patients in Uganda. These findings are congruent with what has been documented in other published African studies among TB patients [5-9]. "
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    ABSTRACT: Vitamin D deficiency has been reported among patients with tuberculosis in Africa despite abundant sunshine. Vitamin D plays a fundamental role in improving anti tuberculosis immunity, reducing progression and severity of TB in humans. In this descriptive cross sectional study, 260 hospitalized adults with a confirmed diagnosis of TB were enrolled into the study from the pulmonology wards of Mulago national referral and teaching hospital, Uganda. The serum concentrations of 25-hydroxyvitamin D or 25 (OH) D were determined by an electrochemilumniscence immunoassay. Vitamin D deficiency, vitamin D insufficiency, severe and very severe vitamin D deficiency were defined as serum 25(OH) D concentrations of <= 20 ng/ml, 21--29 ng\ml, < 10 ng/ml and <5 ng/ml respectively. Majority of the study participants were males (146, 56.2%) and < 35 years (154, 59.2%). The mean age +/- SD was 34.7 +/- 9.5 years. Two hundred eight (80%) patients were HIV co-infected with a median CD4 count of 68 cells/mm3 (IQR: 17--165). The prevalence of vitamin D deficiency, vitamin D insufficiency, severe and very severe vitamin D deficiency among the hospitalized adult tuberculosis patients was 44.2%, 23.5%, 13.5% and 4.2% respectively. The median (IQR) vitamin D concentration in ng/ml was 22.55 (14.59-33.31).Vitamin D deficiency was more prevalent in patients with hypoalbuminemia (97.4%), anemia (86.1%), HIV co-infected patients with CD4 count <200cells/mm3 (83.2%) and hypocalcemia corrected for serum albumin levels (67%). Vitamin D deficiency is very common among hospitalized adult tuberculosis patients in Uganda especially in patients with hypoalbuminemia, anemia, HIV co-infected patients with CD4 count <200cells/mm3 and hypocalcemia corrected for serum albumin levels.
    BMC Research Notes 07/2013; 6(1):293. DOI:10.1186/1756-0500-6-293

  • The International Journal of Tuberculosis and Lung Disease 10/2012; 16(10):1291-9. DOI:10.5588/ijtld.12.0566 · 2.32 Impact Factor
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