Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement: A randomized controlled trial.

Centre for Human Psychopharmacology, NICM Collaborative Centre for Neurocognition, Swinburne University of Technology, 427-451 Burwood Road, Hawthorn, Melbourne, VIC, 3122, Australia.
Psychopharmacology (Impact Factor: 3.99). 03/2012; 220(2):351-65. DOI: 10.1007/s00213-011-2481-3
Source: PubMed

ABSTRACT There is potential for multivitamin supplementation to improve cognition in the elderly. This randomized, double-blind, placebo-controlled trial was conducted to investigate the effects of 16 weeks multivitamin supplementation (Swisse Women's 50+ Ultivite ®) on cognition in elderly women.
Participants in this study were 56 community dwelling, elderly women, with subjective complaints of memory loss. Cognition was assessed using a computerized battery of memory and attention tasks designed to be sensitive to age-related declines to fluid intelligence, and a measure of verbal recall. Biochemical measures of selected nutrients, homocysteine, markers of inflammation, oxidative stress, and blood safety parameters were also collected. All cognitive and haematological parameters were assessed at baseline and 16 weeks post-treatment.
The multivitamin improved speed of response on a measure of spatial working memory, however benefits to other cognitive processes were not observed. Multivitamin supplementation decreased levels of homocysteine and increased levels of vitamin B(6) and B(12), with a trend for vitamin E to increase. There were no hepatotoxic effects of the multivitamin formula indicating this supplement was safe for everyday usage in the elderly.
Sixteen weeks ssupplementation with a combined multivitamin, mineral and herbal formula may benefit working memory in elderly women at risk of cognitive decline.

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Available from: Helen Macpherson, Jul 10, 2015
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    • "Studies on the role of Hcy in cognitive performance in healthy subjects have shown that Hcy is specifically involved in episodic memory (Faux et al., 2011; Narayan et al., 2011), spatial learning (Pirchl et al., 2010), reversal learning (Christie et al., 2005; Algaidi et al., 2006), and executive function (Narayan et al., 2011). However, it is debatable whether Hcy plays a role in working memory processes, as some studies have found they are not related (Narayan et al., 2011), while other studies found that lowering Hcy levels enhances working memory (Macpherson et al., 2012). "
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    ABSTRACT: Although homocysteine (Hcy) has been widely implicated in the etiology of various physical health impairments, especially cardiovascular diseases, overwhelming evidence indicates that Hcy is also involved in the pathophysiology of schizophrenia and affective disorders. There are several mechanisms linking Hcy to biological underpinnings of psychiatric disorders. It has been found that Hcy interacts with NMDA receptors, initiates oxidative stress, induces apoptosis, triggers mitochondrial dysfunction and leads to vascular damage. Elevated Hcy levels might also contribute to cognitive impairment that is widely observed among patients with affective disorders and schizophrenia. Supplementation of vitamins B and folic acid has been proved to be effective in lowering Hcy levels. There are also studies showing that this supplementation strategy might be beneficial for schizophrenia patients with respect to alleviating negative symptoms. However, there are no studies addressing the influence of add-on therapies with folate and vitamins B on cognitive performance of patients with schizophrenia and affective disorders. In this article, we provide an overview of Hcy metabolism in psychiatric disorders focusing on cognitive correlates and indicating future directions and perspectives.
    Frontiers in Behavioral Neuroscience 09/2014; 8. DOI:10.3389/fnbeh.2014.00343 · 4.16 Impact Factor
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    • "The treatments were randomly allocated in blocks of four by the supplier; Swisse Vitamins®. Full details of the clinical trial methods have been described previously [14] "
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    ABSTRACT: OBJECTIVE: Growing evidence suggests that dietary supplementation with selected micronutrients and nutraceuticals may have the potential to improve cognition in older adults. Fewer studies have investigated the effects of these substances on brain activity. METHODS: This study was a randomised, double-blind, placebo-controlled trial, conducted to explore the effects of 16weeks supplementation with a combined multivitamin, mineral and herbal formula on the steady state visually evoked potential (SSVEP) measure of brain electrical activity. Participants were elderly women aged between 64 and 79years, with subjective memory complaints. Baseline and post-treatment SSVEP data was obtained for 22 participants in the multivitamin group and 19 in the placebo group. A spatial working memory delayed response task (DRT) was performed during the recording of the SSVEP. RESULTS: The results revealed that when compared to placebo, multivitamin supplementation delayed SSVEP latency during retrieval, interpreted as an increase in inhibitory neural processes. Behavioural performance on the DRT was not improved by the multivitamin, however improved performance accuracy was associated with increased midline central SSVEP latency. There were no multivitamin-related effects on SSVEP amplitude. CONCLUSION: These findings indicate that in the elderly, multivitamin supplementation may enhance neural efficiency during memory retrieval.
    Physiology & Behavior 08/2012; 107(3):346-354. DOI:10.1016/j.physbeh.2012.08.006 · 3.03 Impact Factor
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    • "However, a study conducted over a shorter period of time (4 months) has reported memory improvements in subjects aged 50–75 years following treatment with a combined antioxidant vitamin, mineral and herbal supplement (Summers et al., 2010). Similar findings have also been reported from another 4-month trial in elderly aged 64–81 years (Macpherson et al., 2012). Herbal components of the formulas used in both studies included flavonoids and Ginkgo biloba, ingredients previously explored for their potential cognitive enhancing effects (Stough et al., 2001; Ferrari, 2004). "
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    ABSTRACT: Nutritional and vitamin status may be related to cognitive function and decline in older adults. The aim of this study was to investigate the effects of nutritional supplementation on cognition in older men. The current study was an 8-week, placebo-controlled, double-blind investigation into the effects of a multivitamin, mineral and herbal supplement (Swisse Men's Ultivite®, Swisse Vitamins Pty Ltd, Melbourne, Australia) on cognitive performance in older men. Participants were 51 male individuals aged between 50 and 74 years, with a sedentary lifestyle. Cognitive performance was assessed at baseline and post-treatment using a computerised battery of cognitive tasks, enabling the measurement of a range of attentional and memory processes. Blood measures of vitamin B(12) , folate and homocysteine were collected prior to and after supplementation. The results of this study revealed that contextual recognition memory performance was significantly improved following multivitamin supplementation (p < 0.05). Performance on other cognitive tasks did not change. Levels of vitamin B(12) and folate were significantly increased with a concomitant decrease in homocysteine, indicating that relatively short-term supplementation with a multivitamin can benefit these risk factors for cognitive decline. Findings from this study indicate that daily multivitamin supplementation may improve episodic memory in older men at risk of cognitive decline.
    Human Psychopharmacology Clinical and Experimental 07/2012; 27(4):370-7. DOI:10.1002/hup.2236 · 1.85 Impact Factor
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