Article

Donation after cardiac death: A 29-year experience

Division of Organ Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-7375, USA.
Surgery (Impact Factor: 3.11). 10/2011; 150(4):692-702. DOI: 10.1016/j.surg.2011.07.057
Source: PubMed

ABSTRACT To report the long-term outcomes of 1218 organs transplanted from donation after cardiac death (DCD) donors from January 1980 through December 2008.
One-thousand two-hundred-eighteen organs were transplanted into 1137 recipients from 577 DCD donors. This includes 1038 kidneys (RTX), 87 livers (LTX), 72 pancreas (PTX), and 21 DCD lungs. The outcomes were compared with 3470 RTX, 1157 LTX, 903 PTX, and 409 lung transplants from donors after brain death (DBD).
Both patient and graft survival is comparable between DBD and DCD transplant recipients for kidney, pancreas, and lung after 1, 3, and 10 years. Our findings reveal a significant difference for patient and graft survival of DCD livers at each of these time points. In contrast to the overall kidney transplant experience, the most recent 16-year period (n = 396 DCD and 1,937 DBD) revealed no difference in patient and graft survival, rejection rates, or surgical complications but delayed graft function was higher (44.7% vs 22.0%; P < .001). In DCD LTX, biliary complications (51% vs 33.4%; P < .01) and retransplantation for ischemic cholangiopathy (13.9% vs 0.2%; P < .01) were increased. PTX recipients had no difference in surgical complications, rejection, and hemoglobin A1c levels. Surgical complications were equivalent between DCD and DBD lung recipients.
This series represents the largest single center experience with more than 1000 DCD transplants and given the critical demand for organs, demonstrates successful kidney, pancreas, liver, and lung allografts from DCD donors.

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    • "Other groups with more than 15 years of experience report a DGF of 44.7% (n ¼ 396 DCD) and graft survival at 1, 3, and 10 years to be 78.2%, 68.5%, and 41.6%, respectively, among DCD kidney transplants and for DBD 78.2%, 68.5%, and 41.3%, respectively [11]. There is no consensus regarding technical aspects such as the use of ante-mortem cannulation, biopsy, and perfusion machines. "
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    ABSTRACT: To increase the number of kidney donors, new strategies are needed such as living donor programs, expanded criteria donors, or donors after circulatory death (DCD) kidney transplantation programs. The GEODAS group has started an observational, prospective, multicenter clinical study, collecting data from all DCD type-3 kidney transplantations performed in seven Spanish hospitals from January 2012 to January 2014. The preliminary results have shown a delayed graft function of 40.4% and graft survival of 93.7% with a nadir creatinine of 1.3 mg/dL. From all 33 potential donors included in the study, 32 were effective and 63 kidney grafts were transplanted with a utilization rate of 98.5%. Creatinine evolution (median [range]) was in the first month: 2.1 [0.6-5.6]; third month: 1.6 [0.8, 4.2]; first year: 1.6 [0.9-2.2]. These results are similar to kidney transplantation from donors after brain death as shown in the literature, especially in the graft and recipient survival rates. In addition, the controlled programs are easier and less expensive than uncontrolled DCD programs with a higher rate of graft use. Copyright © 2015 Elsevier Inc. All rights reserved.
    Transplantation Proceedings 02/2015; 47(1):27-9. DOI:10.1016/j.transproceed.2014.12.008 · 0.95 Impact Factor
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    • "A recent study, prepared on behalf of European Committee on Organ Transplantation, identified 10 countries in Europe that have adopted or are in the process of adopting policies to promote the use of DCD [18]. The United States and Canada have both vigorously pursued DCD policies [19], [20], [21], and in Latin America, DCD donation has also been reported in Bolivia, Brazil and Colombia. In Australia, the Commonwealth Government recently allocated large amounts of funding [22] to support strategies aimed at improving its consistently low deceased organ donation rates, including the adoption of policies that promote DCD [23]. "
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