The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology.
ABSTRACT Plants of the genus Desmodium (Fabaceae), such as Desmodium styracifolium (Osbeck) Merr. and Desmodium gyrans (L. f.) DC., have a long history of medical use in Traditional Chinese Medicine to treat various ailments including rheumatism, pyrexia, dysentery, wounds, cough, malaria, hepatitis, hemoptysis, etc. In the theory of Traditional Chinese Medicine, most species have the effect of relieving internal heat or fever, neutralizing toxins, inhibiting pain, invigorating blood circulation, suppressing cough and alleviating dyspnea.
A bibliographic investigation was accomplished by analyzing secondary sources including Chinese Herbal Classics, and worldwide accepted scientific databases (Pubmed, Scopus and Web of Science, SciFinder) were scrutinized for the available information on the ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and toxicology of Desmodium species.
The genus Desmodium is a large member of the Papilionaceae (Fabaceae) family. It contains about 350 plant species used for both feeding stuffs and herbal medicines, of which only about 30 species have been phytochemically or pharmacologically investigated. Desmodium plant extracts, as well as the active principles, have been experimentally studied for their anti-inflammatory, cytotoxic, antidiabetic, antinephrolithic, antibacterial, and nootropic activities in vitro or in vivo. And so far, a total of 212 compounds have been isolated from 15 Desmodium species and characterized mainly as flavonoids and alkaloids, followed by terpenoids, steroids, phenols, phenylpropanoids, glycosides and a number of volatile oils. The remaining unrevealed species are recorded chiefly in Asia and Africa being used in empirical treatment for various diseases.
Desmodium species have long been used in TCM to treat various ailments. Available scientific references revealed that the traditional medical uses of some important Desmodium species in TCM have been evaluated by modern pharmacological studies. As literature demonstrated, flavonoids and alkaloids are perhaps responsible for most of the activities shown by the plants of this genus. Further studies are still required to reveal the structure-activity relationship of these active constituents.
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ABSTRACT: Objective: Selected medicinal plants are either singly or in combination have been used traditionally for the management of variety of conditions especially against inflammatory disorders. They include Aegle marmelos (L.) Corr., Desmodium gangeticum (L.) DC., Gmelina arborea Roxb., Oroxylum indicum Vent., Premna optusifolia R. Br., Solanum anguivi Lam., Solanum virginianum L., Stereospermum colais Mabb. Tribulus terrestris L. and Uraria picta (Jacq.) Desv. ex DC. They are the constitutents of Ayurvedic Dashamoola which is a combination of roots of ten plants, owing to a unique combination of ten plants that play specific role in treatment of different conditions. Few of them are known to possess anti-inflammatory activity individualy but comparative study of these plants has never been carried out, therefore we have comparatively investigated these plants for their anti-inflammatory activity. Method: Water decoctions of rootswere administered orally using in vivo Carrageenan induced rat paw edema model. Result: Plants viz. Aegle marmelos (28.20%), Premna optusifolia (25.78%), Oroxylum indicum (24.15%), Desmodium gangeticum (26.74%), Uraria picta (21.49%) exhibited highest anti-inflammatory activity at a dose of 1.8 ml/kg b.w. Conclusion: plants possessing maximum anti-inflammatory activity can be used more effectively to cure inflammatory ailments. They might be responsible for anti-inflammatory activity of Dashamoola formulation.International Journal of Pharmacy and Pharmaceutical Sciences 06/2013; 5(3):239-243. · 1.59 Impact Factor
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ABSTRACT: Abstract Context: Podocarpium podocarpum (DC.) Yang et Huang (Leguminoseae) is a very important Podocarpium species with significant anti-inflammatory, analgesic and anti-pyretic activities, which has not yet been subjected to adequate phytochemical investigation. Objective: To isolate and identify bioactive compounds from P. podocarpum. Materials and methods: Ethanol extract of the whole plant of P. podocarpum was subjected to repeated column chromatography. Chemical structures of the compounds were identified by 1D, 2D-NMR spectra and MS data. Human cervical carcinoma (HeLa) and pancreatic carcinoma (PANC-1) cell lines were employed to evaluate the in vitro cytotoxic activity of the isolated constituents at six concentrations (0.001, 0.01, 0.1, 1.0, 10.0, 100.0 μg/ml). Results: A new phenylpropanoid glycoside, podocarioside A (1), together with four known compounds, (E)-3-(4-hydroxy-3-propoxyphenyl) acrylic acid (2), schizandrin (3), dehydrodiconiferyl alcohol (4) and dihydrodehydrodiconiferyl alcohol (5), were isolated from P. podocarpum. Compounds 1, 3 and 4 showed moderate cytotoxic against HeLa cells with IC50 values of 38.62, 8.64 and 5.85 μg/mL, respectively, while none exhibited toxicity against PANC-1 cells. Discussion and conclusion: This is the first report on the isolation and identification of bioactive compounds from P. podocarpum. In vitro cytotoxic assay of the isolated constituents establishes the potential of those components as antitumor agents.Pharmaceutical Biology 06/2013; · 1.21 Impact Factor