Very little high-quality evidence to support most medications for children with autism spectrum disorders

Nationwide Children's Hospital, Columbus, Ohio, USA.
The Journal of pediatrics (Impact Factor: 3.79). 11/2011; 159(5):872-3. DOI: 10.1016/j.jpeds.2011.09.005
Source: PubMed
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    ABSTRACT: Medication adherence in children is poor, particularly among those with chronic or mental health disorders. However, adherence has not been fully assessed in autism spectrum disorders (ASDs). The validated proportion of days covered method was used to quantify adherence to psychotropic medication in Medicaid-eligible children who met diagnostic criteria for ASD between 2000 and 2008 (N = 628). Among children prescribed attention deficit hyperactivity disorder (ADHD) medications, antidepressants, or antipsychotics, 44, 40 and 52 % were adherent respectively. Aggressive behaviors and abnormalities in eating, drinking, and/or sleeping, co-occurring ADHD, and the Medication Regimen Complexity Index were the most significant predictors of adherence rather than demographics or core deficits of ASD. Identifying barriers to adherence in ASD may ultimately lead to improved treatment outcomes.
    Journal of Autism and Developmental Disorders 06/2014; 44(11). DOI:10.1007/s10803-014-2156-0 · 3.34 Impact Factor

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