A comprehensive glossary of autophagy-related molecules and processes (2(nd) edition)

Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Autophagy (Impact Factor: 11.42). 11/2011; 7(11):1273-94. DOI: 10.4161/auto.7.11.17661
Source: PubMed

ABSTRACT The study of autophagy is rapidly expanding, and our knowledge of the molecular mechanism and its connections to a wide range of physiological processes has increased substantially in the past decade. The vocabulary associated with autophagy has grown concomitantly. In fact, it is difficult for readers--even those who work in the field--to keep up with the ever-expanding terminology associated with the various autophagy-related processes. Accordingly, we have developed a comprehensive glossary of autophagy-related terms that is meant to provide a quick reference for researchers who need a brief reminder of the regulatory effects of transcription factors and chemical agents that induce or inhibit autophagy, the function of the autophagy-related proteins, and the roles of accessory components and structures that are associated with autophagy.

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Available from: Daniel J Klionsky, Aug 25, 2015
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    • "Assembly of genes involved in mitochondrial dynamic gene categories comprising mitochondrial fusion and fission, mitochondrial DNA replication and biogenesis regulation, mitochondrial repair and protection systems, macroautophagy initiation and nucleation regulation, autophagosome expansion and ATG conjugation, syntaxin/SNAREs [SNAP (Soluble NSF Attachment Protein) REceptor], selective macroautophagy (including mitophagy), autophagosome trafficking facilitation, and lysosomal fusion, lysosomal biogenesis, proteasome assembly, E1 ubiquitin activators, E2 ubiquitin conjugation enzymes, E3 ubiquitin ligases, ubiquitin, etc, and heat shock proteins70/40/27/22kDa also were analyzed using a combination of resources as a template, including the HUGO gene name consortium (, NCBI tools, ENSEMBLE genome browser, by hand search of the literature, and autophagy genes determined largely based around the 2nd edition glossary of autophagy terms and processes (Klionsky et al. 2011) (Figure 7 and File S3). Determination of lens epithelial (EC and EQ regions) or fiber cell (FP and FC regions) expression preference for a given nuclear encoded mitochondrial regulatory transcript was determined by Figure 2 Identification of differentially expressed transcripts. "
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