Associated Morbidity of Chalazia
ABSTRACT Chalazion may be associated with some local and systemic conditions. We studied the prevalence of various conditions among patients with chalazion.
A retrospective observational case-control study of all the members who were diagnosed with chalazion in the Central District of Clalit Health Services in Israel (years 2000-2008; n = 9119) and 9119 age- and gender-matched controls randomly selected from the district members. We calculated the prevalence of various ocular, systemic, and demographic conditions as risk factors for chalazion.
Demographically, a significant (P < 0.0001) tendency to develop chalazion was found in the population of lower socioeconomic class, in the population living in urban areas, in young females (10-29 years), in older men (older than 60 years), and in non-Ashkenazi Jews. The following risk factors of chalazion were statistically significant: blepharitis [odds ratio (OR), 6.2], rosacea (OR, 2.9), gastritis (OR, 1.4), anxiety (OR, 1.5), irritable bowel syndrome (OR, 1.7), and smoking (OR, 1.2). Diabetes (OR, 0.8) and hypothyroidism (OR, 0.8) were significantly less prevalent among chalazion patients.
Some systemic conditions are significantly more prevalent and some are significantly less prevalent among patients with chalazion. Better understanding of the pathophysiological association between those diseases and chalazion may help in its treatment and prevention.
Article: Periocular Lesions, Part One[Show abstract] [Hide abstract]
ABSTRACT: The evaluation and management of periocular lesions is often a daunting task for the healthcare provider primarily because of the proximity to the eye(s). For those working outside of the field of ophthalmology, lesions present within the ocular adnexa are often ignored, misdiagnosed, or mistreated because of minimal training in this specialty area. This article represents the first in a series of four articles focusing on proper identification, evaluation, and management of common periocular lesions. The commencement of this series will focus on common inflammatory lesions and, more specifically, on hordeola and chalazia.01/2013; 5(1):19-22. DOI:10.1097/JDN.0b013e31827e8628
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ABSTRACT: PURPOSE: To quantitatively evaluate effects of ceramide (Cer) and free cholesterol (FC) on meibomian lipid films (MLF) using a Langmuir trough (LT) and a Brewster angle microscope (BAM). METHODS: Meibum was obtained from healthy volunteers. A series of mixtures of meibum with Cer or FC (mixed MLF) taken in different ratios were tested. Standard rheological parameters such as elasticity and hysteresis of MLF were computed. BAM was used to study their morphology. RESULTS: Pure MLF were capable of withstanding multiple compression-expansion cycles with little hysteresis observed (0.3J/g meibum). The films made of either pure Cer or pure FC were clearly collapsible and had much higher a rigidity and hysteresis than pure meibum. Adding progressively higher amounts of Cer or FC to meibum had a strong impact on the rigidity, stability, and morphology of the mixed MLF: their hysteresis increased manifold compared to pure meibum. A concomitant increase in the rigidity and collapsibility of the mixed MLF was observed. CONCLUSIONS: Cer and FC changed the surface properties of mixed MLF in a way that implied their destabilization and/or disruption. One of the mechanisms that might lead to these effects is strong aggregation of meibum lipids with FC or Cer that leads to the formation of smaller particles of meibum surrounded by a thinner layer of FC or Cer. As Cer and FC can be elevated in meibum and the tear film because of certain pathological processes, or can be of exogenous nature, our results can (partially) explain a less stable tear film in those subjects.Investigative ophthalmology & visual science 01/2013; 54(2). DOI:10.1167/iovs.12-10662 · 3.66 Impact Factor
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ABSTRACT: To investigate the correlation between demodicosis and chalazia in patients with the latter. Prospective, observational, comparative study. Forty-four adult and 47 pediatric patients with chalazia and 34 adult and 30 pediatric age- and sex-matched patients without chalazia treated at an institutional referral eye center were included. All 155 patients underwent lash sampling followed by microscopic identification and counting of Demodex mites. All 91 patients with chalazia underwent surgical removal, and among them, 74 were followed up for 18 ± 4.3 months after surgery. Statistical correlation between ocular demodicosis and chalazia and its postoperative recurrence was performed. Demodicosis was significantly more prevalent in chalazia patients than in control patients as a group (69.2% vs 20.3%) and when separated into pediatric (70.2% vs 13.3%) and adult (68.2% vs 26.5%) subgroups (all P < .001). Demodicosis was associated strongly with chalazia (odds ratio, 4.39; 95% confidence interval, 2.17 to 8.87; P < .001). D. brevis was significantly more prevalent (odds ratio, 18.21; 95% confidence interval, 2.22 to 149.74; P = .01) than D. folliculorum (odds ratio, 2.82; 95% confidence interval, 1.16 to 6.84, P = .02) in patients with chalazia. Patients with demodicosis tended to demonstrate recurrence (33.3% vs 10.3%; P = .02), especially in those with D. brevis (35.1% vs 13.5%; P = .03). There is a high prevalence of demodicosis, especially cases of caused by D. brevis, in adult and pediatric patients with chalazia, suggesting that ocular demodicosis is a risk factor for chalazia.American Journal of Ophthalmology 10/2013; 157(2). DOI:10.1016/j.ajo.2013.09.031 · 4.02 Impact Factor