Article

Hematologic failure.

Department of Vascular Medicine/Internal Medicine, University of Amsterdam, The Netherlands.
Seminars in Respiratory and Critical Care Medicine (impact factor: 2.43). 10/2011; 32(5):651-9. DOI:10.1055/s-0031-1287873 pp.651-9
Source: PubMed

ABSTRACT Hematologic factors, in particular platelets and the coagulation system, play an important role in the pathogenesis of organ failure in the intensive care unit. Failure of these hematologic systems is common in intensive care patients and may range from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for a deranged coagulation in critically ill patients, and each of these underlying disorders may require specific therapeutic management. Hence, a proper differential diagnosis and initiation of adequate (supportive) treatment strategies are crucial to reduce morbidity and mortality in critically ill patients with coagulation abnormalities.

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Keywords

coagulation abnormalities
 
coagulation system
 
complex defects
 
critically ill patients
 
deranged coagulation
 
disseminated intravascular coagulation
 
global clotting tests
 
Hematologic factors
 
hematologic systems
 
intensive care patients
 
intensive care unit
 
organ failure
 
proper differential diagnosis
 
underlying disorders
 

Marcel Levi