T-Cell Lymphoma with Immune-Mediated Anemia and Thrombocytopenia in a Horse

College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
Journal of Veterinary Internal Medicine (Impact Factor: 2.06). 09/2011; 25(5):1181-5. DOI: 10.1111/j.1939-1676.2011.00777.x
Source: PubMed
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    ABSTRACT: A 3-year-old pregnant Standardbred mare was treated at the University of Helsinki Equine Teaching Hospital for severe idiopathic immune-mediated thrombocytopenia and haemolytic anaemia (Evan's syndrome). Despite initial improvement with supportive care and immunosuppressive doses of corticosteroids and azathioprine, the mare died from a fatal cerebral haemorrhage on Day 21 of treatment.
    07/2013; 25(7). DOI:10.1111/j.2042-3292.2012.00432.x
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    ABSTRACT: Horse production is a major animal industry in Portugal with horses being bred and trained for for several purposes, including sport (jumping, dressage, horseball), leisure riding, bullfighting, working as draft animals, etc. Strongyles are a very important group of equine parasites, and there are some seventy differenty species of helminths in this group that are found in horses. The identification of adult strongyles to species is important because it provides information on population of these worms within a horse and suggests the potential risk of the helminths present producing diarrhoea or colic, being associated with anthelmintic resistance, and the effects of animal hunsbandry on their control. Studies comparing worms present within the intestine at post mortem with the adult and larval stages shed in faecal samples of horses on the same farms have shown high degrees of corrlleation. Thus, for clinical and epidemiological surveys, along with the assessment of deworming efficacy programmes,; a great deal can be learned without the need to recover worms from horses at necropsy. Over several years, 23 horses were selected that had diarrhoea with the natural shedding of adult strongyles in faeces (N=3) or after deworming (N=20). A faecal sample was collected after defecation or 24-48 h after deworming. All 23 horses were found positive for adult stages of strongyles, 30,4% for Strongylinae and 100% for Cyathostominae, in a total of 2628 worms belonging to 10 genera and 24 species of strongyles (4 Strongylinae and 20 Cyathostominae). Nematodes of subfamily Cyathostominae contributed to 99,7% of the total number of collected strongyles, while Strongylinae comprised only 0,34%. An average of 8 species/host (minimum 1 and maximum 17) and 114 worms/sample/host (minimum 1 and maximum 373) were found. The 10 most prevalent species in subfamily Cyathostominae (Cylicocyclus insigne, Cylicocyclus nassatus, Cyathostomum catinatum, Cylicostephanus longibursatus, Cylicocyclus asworthi, Cyathostomum pateratum, Cylicostephanus calicatus, Coronocyclus coronatus, Cylicocyclus leptostomum, Coronocyclus labiatus), comprised 93,3 % of total studied strongyles, being C. nassatus the most abundant one, contributing to 35 % of the total worm count. There was a marked reduction in the Strongylinae, namely S. vulgaris, when compared with Cyathostominae, which comprised 99,7% of the total number of strongyles. This approach to the study of strongyle populations within horses produced very useful data concerning the dominance of cyathostomins when relatvied to the entire strongyle population, provided for the identification of a large number of strongyle species (24), and represents a potentially valid alternative to parasitological studies requiring euthanasia for the purpose of necropsies for worm recovery.
    Horses: Breeding, Health Disorders and Effects on Performance & Behavior, 1st edited by ADOLFO PAZ-SILVA, MARÍA SOL ARIAS & RITA SANCHÉZ-ANDRADE, 03/2014: chapter Strongyles Shed in Faeces As a Means of Monitoring the Parasite Scenario in Horse Stud Farms: pages 93-125; Nova Science Publishers, New York, USA.
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    Horses: Breeding, Health Disorders and Effects on Performance & Behavior, 1st edited by ADOLFO PAZ-SILVA, MARÍA SOL ARIAS, RITA SANCHÉZ-ANDRADE, 03/2014: chapter Horse handling Conditions and Emergence of Neglected Infections: Fasciolosis.: pages 127-143; Nova Science Publishers, New York, USA., ISBN: 978-1-63117-560-2