T-Cell Lymphoma with Immune-Mediated Anemia and Thrombocytopenia in a Horse

College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
Journal of Veterinary Internal Medicine (Impact Factor: 1.88). 09/2011; 25(5):1181-5. DOI: 10.1111/j.1939-1676.2011.00777.x
Source: PubMed
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    ABSTRACT: A 3-year-old pregnant Standardbred mare was treated at the University of Helsinki Equine Teaching Hospital for severe idiopathic immune-mediated thrombocytopenia and haemolytic anaemia (Evan's syndrome). Despite initial improvement with supportive care and immunosuppressive doses of corticosteroids and azathioprine, the mare died from a fatal cerebral haemorrhage on Day 21 of treatment.
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    ABSTRACT: Bench-top blood typing uses specialized antisera to identify the red blood cell (RBC) antigens. Crossmatching is used to detect incompatible antibodies in plasma/serum of the donor and patient that will react with RBC blood types of the patient and donor, respectively. Immune-mediated hemolytic anemia (IMHA) is the premature destruction of RBCs due to the presence of antibodies directed against RBC antigens. Neonatal isoerythrolysis is the most common cause for icterus and hemolytic anemia in the neonatal foal. Hemostasis is the arrest of bleeding or stoppage of blood flow through a vessel required for the control of bleeding associated with daily trauma or surgery. An understanding of the classic description of hemostasis is useful in the interpretation of coagulation testing. This chapter discusses both classical and cell-based hemostatic models in detail. Coagulation testing is used clinically when a patient is bleeding without obvious trauma, bleeding excessively from a surgical/traumatic wound.
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    ABSTRACT: The complete blood count (CBC) provides information beyond the concentrations of blood cells. Insight into disease processes and their severity and even diagnoses can be gleaned from a thorough evaluation of the CBC, especially in conjunction with a peripheral blood film. The leukogram includes the numeric and morphologic data pertaining to white blood cells. Distinct leukogram profiles are associated with inflammation, corticosteroids, and epinephrine. In horses, platelet number and size are shown to be directly proportional rather than inversely proportional as in some species. More than the erythrocytes of any other domestic species, equine erythrocytes have a strong tendency for rouleau formation that is characterized by “coin-stacking.” The types of poikilocytosis encountered in equine hematology are similar to poikilocytosis in other species. Mature lymphocytes are the smallest of the blood leukocytes and have a round nucleus, condensed chromatin, and scant basophilic rim of cytoplasm.
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