Article

Synthesis and biological activity of ethyl 2-(substituted benzylthio)-4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate derivatives.

School of Chemistry, University of Kwa-Zulu Natal, Durban, South Africa.
Archiv der Pharmazie (impact factor: 1.71). 02/2012; 345(2):163-8. DOI:10.1002/ardp.201100133
Source: PubMed

ABSTRACT In the present study, a new series of ethyl 2-(substituted benzylthio)-4-(3'-(ethoxycarbonyl)-biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate derivatives was synthesized. The newly synthesized compounds were characterized by (1) H-NMR, mass and C, H, N analyses. All newly synthesized compounds were screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pyogenes and Klebsiella pneumoniae) and antifungal (Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Penicillium marneffei and Trichophyton mentagrophytes) activity. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Compounds 8a, 8b, 8c, 8e, 8f, 8i, and 8j exhibited good antimicrobial activity.

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Keywords

8j exhibited good antimicrobial activity
 
Aspergillus flavus
 
Compounds 8a
 
Escherichia coli
 
ethyl 2-(substituted benzylthio)-4-(3'-(ethoxycarbonyl)-biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate derivatives
 
new series
 
Penicillium marneffei
 
Pseudomonas aeruginosa
 
significant biological activity
 
Staphylococcus aureus
 
Streptococcus pyogenes
 
synthesized compounds
 
tested microorganisms