Reduction of Risk for Cardiovascular Disease in Children and Adolescents

Department of Pediatrics, University of Colorado School of Medicine, The Children's Hospital, Aurora, CO 80045, USA.
Circulation (Impact Factor: 14.43). 10/2011; 124(15):1673-86. DOI: 10.1161/CIRCULATIONAHA.110.016170
Source: PubMed
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    • "Autopsy studies have shown that early coronary atherosclerosis o f t e n b eg i n s i n c h i l d h o o d a n d a d o l e s c e n c e . F u r t h e r, hypercholesterolaemia in adolescents correlated positively with changes in vasculature predictive of later CVD[9]. There is a tendency to persistence in ranks (tracking) for total serum and β-lipoprotein cholesterol with age[10]. "
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    ABSTRACT: To study the differences between the lipid profiles of the subjects whose parents are having known non-modifiable risk factors such as obesity, hypertension (HTN), myocardial infarction and diabetes, and compare them with the lipid profiles of the subjects whose parents are not having those risk factors.
    Asian Pacific Journal of Tropical Biomedicine 02/2015; 5(2). DOI:10.1016/S2221-1691(15)30154-4
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    • "Ringseis & Eder (2010) contend that there is 'a clear need for developing strategies to prevent atherosclerosis' . Obesity is an independent risk factor for CVD and stroke (Ezzati et al. 2007; Daniels et al. 2011). Physical inactivity itself causes endothelial dysfunction, CVD and stroke (Suvorava et al. 2004; Laufs et al. 2005; Hamburg et al. 2007). "
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    ABSTRACT: Key points  Sedentary and high-fat diet lifestyles are associated with greater prevalence of obesity and type 2 diabetes in humans, both of which independently increase atherosclerosis.  High-fat diet in sedentary individuals produces endothelial dysfunction in blood vessels as a first step toward coronary arteriosclerosis.  We observed preservation of coronary arteriolar vascular function when mice began voluntary running in wheels at the start of a high-fat diet.  We further showed that mechanisms by which running opposed the detrimental effects of high-fat diet on vascular function included maintenance of eNOS phosphorylation, leptin sensitivity, and redox balance in mouse coronary arterioles.  The results provide evidence for how physical activity is an effective therapy to oppose the development of atherosclerosis in the first place.
    The Journal of Physiology 06/2012; 590(Pt 17):4255-68. DOI:10.1113/jphysiol.2012.234856 · 5.04 Impact Factor
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    • "Particularly worrisome is the 10.4% prevalence of obesity among the 2 to 5 year olds in the US12, with other parts of the world catching up13, 14. The World Health Organization (WHO) defines obesity (in adults: BMI >30 kg/m2) as a disease for which excessive calorie intake, in conjunction with lack of physical exercise, have been identified as major predisposing and aggravating factors15, 16. Obesity also serves as soil for the development of other diseases15, particularly insulin resistance (pre-diabetes), type 2 diabetes mellitus, arterial hypertension, dyslipidemia/hypertriglyceridemia, and fatty liver disease/non-alcoholic steatohepatitis (NASH)15, 17, 18. "
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    ABSTRACT: Childhood obesity has become major health concern for physicians, parents, and health agencies around the world. Childhood obesity is associated with an increased risk for other diseases not only during youth but also later in life, including diabetes, arterial hypertension, coronary artery disease, and fatty liver disease. Importantly, obesity accelerates atherosclerosis progression already in children and young adults. With regard to pathophysiological changes in the vasculature, the striking similarities between physiological changes related to aging and obesity-related abnormalities are compatible with the concept that obesity causes "premature" vascular aging. This article reviews factors underlying the accelerated vascular disease development due to obesity. It also highlights the importance of recognizing childhood obesity as a disease condition and its permissive role in aggravating the development of other diseases. The importance of childhood obesity for disease susceptibility later in life, and the need for prevention and treatment are also discussed.
    Acta Pharmacologica Sinica 02/2012; 33(2):189-93. DOI:10.1038/aps.2011.204 · 2.91 Impact Factor
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