Article

Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter.

The Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, South Korea.
FEBS letters (impact factor: 3.54). 11/2011; 585(21):3436-41. DOI:10.1016/j.febslet.2011.09.035 pp.3436-41
Source: PubMed

ABSTRACT Reactive oxygen species (ROS) caused oxidative stress plays a key role in carcinogenesis. The POU domain transcription factor Oct-1 and catalase is closely associated with ROS. However, a correlation between these two key proteins has not been demonstrated before. In this report, we show that Oct-1 acts as an activator of catalase, by binding to the catalase promoter in hepatocellular carcinoma (HCC) cell lines. In addition, we suggest that Oct-1 is downregulated by ROS via CpG island methylation in its promoter. These findings contribute to a better understanding of the epigenetic changes induced by ROS in the process of carcinogenesis.

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Keywords

activator
 
CpG island methylation
 
epigenetic changes induced
 
hepatocellular carcinoma
 
Oct-1
 
Oct-1 acts
 
oxidative stress
 
POU domain transcription factor Oct-1
 
Reactive oxygen species
 
ROS
 
two key proteins