Article

Definitions and classification of work-related asthma.

Department of Chest Medicine, Hôpital du Sacré-Cœur, Université de Montréal, 5400 West Gouin Boulevard, Montreal H4J 1C5, Canada.
Immunology and allergy clinics of North America (impact factor: 3.18). 11/2011; 31(4):645-62, v. DOI:10.1016/j.iac.2011.07.003 pp.645-62, v
Source: PubMed

ABSTRACT The workplace can trigger or induce asthma and cause the onset of different types of work-related asthma (WRA). Based on current knowledge of clinical features, pathophysiologic mechanisms, and evidence supporting a causal relationship, the following conditions should be distinguished in the spectrum of WRA: (1) immunologic occupational asthma (OA), (2) nonimmunologic OA, (3) work-exacerbated asthma, and (4) variant syndromes, including eosinophilic bronchitis, potroom asthma, and asthmalike disorders caused by organic dusts. The rationale, issues, and controversies relating to this approach are critically reviewed to stimulate the development of a consensus on operational definitions of the various phenotypes of WRA.

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Keywords

asthmalike disorders
 
causal relationship
 
clinical features
 
current knowledge
 
different types
 
eosinophilic bronchitis
 
induce asthma
 
operational definitions
 
organic dusts
 
pathophysiologic mechanisms
 
various phenotypes
 

Jean-Luc Malo