Article

Can perceptual learning be used to treat amblyopia beyond the critical period of visual development?

Visual Neuroscience Group, School of Psychology, The University of Nottingham, Nottingham, UK.
Ophthalmic and Physiological Optics (Impact Factor: 2.66). 11/2011; 31(6):564-73. DOI: 10.1111/j.1475-1313.2011.00873.x
Source: PubMed

ABSTRACT Amblyopia presents early in childhood and affects approximately 3% of western populations. The monocular visual acuity loss is conventionally treated during the 'critical periods' of visual development by occluding or penalising the fellow eye to encourage use of the amblyopic eye. Despite the measurable success of this approach in many children, substantial numbers of people still suffer with amblyopia later in life because either they were never diagnosed in childhood, did not respond to the original treatment, the amblyopia was only partially remediated, or their acuity loss returned after cessation of treatment.
In this review, we consider whether the visual deficits of this largely overlooked amblyopic group are amenable to conventional and innovative therapeutic interventions later in life, well beyond the age at which treatment is thought to be effective.
There is a considerable body of evidence that residual plasticity is present in the adult visual brain and this can be harnessed to improve function in adults with amblyopia. Perceptual training protocols have been developed to optimise visual gains in this clinical population. Results thus far are extremely encouraging; marked visual improvements have been demonstrated, the perceptual benefits transfer to new visual tasks and appear to be relatively enduring. The essential ingredients of perceptual training protocols are being incorporated into video game formats, facilitating home-based interventions.
Many studies support perceptual training as a tool for improving vision in amblyopes beyond the critical period. Should this novel form of treatment stand up to the scrutiny of a randomised controlled trial, clinicians may need to re-evaluate their therapeutic approach to adults with amblyopia.

0 Followers
 · 
188 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Several recent studies have shown that perceptual learning can result in improvements in reading speed for people with macular disease (e.g., Chung, 2011; Tarita-Nistor et al., 2014). The improvements were reported as an increase in reading speed defined by specific criteria; however, little is known about how other properties of the reading performance or the participants' perceptual responses change as a consequence of learning. In this paper, we performed detailed analyses of data following perceptual learning using an RSVP (rapid serial visual presentation) reading task, looking beyond the change in reading speed defined by the threshold at a given accuracy on a psychometric function relating response accuracy with word exposure duration. Specifically, we explored the statistical characteristics of the response data to address two specific questions: was there a change in the slope of the psychometric function and did the improvements in performance occur consistently across different word exposure durations? Our results show that there is a general steepening of the slope of the psychometric function, leading to non-uniform improvements across stimulus levels.
    Frontiers in Psychology 12/2014; 5:1434. DOI:10.3389/fpsyg.2014.01434 · 2.80 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Amblyopia is a visual disorder due to an abnormal pattern of functional connectivity of the visual cortex and characterized by several visual deficits of spatial vision including impairments of visual acuity (VA) and of the contrast sensitivity function (CSF). Despite being a developmental disorder caused by reduced visual stimulation during early life (critical period), several studies have shown that extensive visual perceptual training can improve VA and CSF in people with amblyopia even in adulthood. With the present study we assessed whether a much shorter perceptual training regime, in association with high-frequency transcranial electrical stimulation (hf-tRNS), was able to improve visual functions in a group of adult participants with amblyopia. Results show that, in comparison with previous studies where a large number sessions with a similar training regime were used (Polat et al., 2004), here just eight sessions of training in contrast detection under lateral masking conditions combined with hf-tRNS, were able to substantially improve VA and CSF in adults with amblyopia.
    Frontiers in Psychology 12/2014; 5. DOI:10.3389/fpsyg.2014.01402 · 2.80 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Perceptual learning has been shown to produce an improvement of visual acuity (VA) and contrast sensitivity (CS) both in subjects with amblyopia and refractive defects such as myopia or presbyopia. Transcranial random noise stimulation (tRNS) has proven to be efficacious in accelerating neural plasticity and boosting perceptual learning in healthy participants. In this study, we investigated whether a short behavioral training regime using a contrast detection task combined with online tRNS was as effective in improving visual functions in participants with mild myopia compared to a 2-month behavioral training regime without tRNS (Camilleri et al., 2014). After 2 weeks of perceptual training in combination with tRNS, participants showed an improvement of 0.15 LogMAR in uncorrected VA (UCVA) that was comparable with that obtained after 8 weeks of training with no tRNS, and an improvement in uncorrected CS (UCCS) at various spatial frequencies (whereas no UCCS improvement was seen after 8 weeks of training with no tRNS). On the other hand, a control group that trained for 2 weeks without stimulation did not show any significant UCVA or UCCS improvement. These results suggest that the combination of behavioral and neuromodulatory techniques can be fast and efficacious in improving sight in individuals with mild myopia.
    Frontiers in Psychology 10/2014; 5. DOI:10.3389/fpsyg.2014.01234 · 2.80 Impact Factor

Full-text (2 Sources)

Download
98 Downloads
Available from
Jun 2, 2014