Cancer Survivorship: Focusing on Future Research Opportunities

Cancer Epidemiology Biomarkers & Prevention (Impact Factor: 4.13). 10/2011; 20(10):1994-5. DOI: 10.1158/1055-9965.EPI-11-0837
Source: PubMed
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    ABSTRACT: Although obesity is a well-known risk factor for several cancers, its role on cancer survival is poorly understood. We conducted a systematic literature review to assess the current evidence evaluating the impact of body adiposity on the prognosis of the three most common obesity-related cancers: prostate, colorectal, and breast. We included 33 studies of breast cancer, six studies of prostate cancer, and eight studies of colo-rectal cancer. We note that the evidence overrepresents breast cancer survivorship research and is sparse for prostate and colorectal cancers. Overall, most studies support a relationship between body adiposity and site-specific mortality or cancer progression. However, most of the research was not specifically designed to study these outcomes and, therefore, several methodological issues should be considered before integrating their results to draw conclusions. Further research is urgently warranted to assess the long-term impact of obesity among the growing population of cancer survivors.
    Annual Review of Nutrition 04/2012; 32(1):311-42. DOI:10.1146/annurev-nutr-071811-150713 · 8.36 Impact Factor
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    ABSTRACT: Unlabelled: There is a need to better understand the posttreatment concerns of the nearly 14 million survivors of cancer alive in the United States today and their receipt of care. Using data from 2,910 posttreatment survivors of cancer from the 2006 or 2010 LIVESTRONG Surveys, the authors examined physical, emotional, and practical concerns, receipt of care, and trends in these outcomes at the population level. Results: 89% of respondents reported at least one physical concern (67% received associated posttreatment care), 90% reported at least one emotional concern (47% received care), and 45% reported at least one practical concern (36% received care). Female survivors, younger survivors, those who received more intensive treatment, and survivors without health insurance often reported a higher burden of posttreatment concerns though were less likely to have received posttreatment care. These results reinforce the importance of posttreatment survivorship and underscore the need for continued progress in meeting the needs of this population. Efforts to increase the availability of survivorship care are extremely important to improve the chances of people affected by cancer living as well as possible in the posttreatment period.
    Journal of Psychosocial Oncology 12/2013; 32(2). DOI:10.1080/07347332.2013.874004 · 1.04 Impact Factor
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    ABSTRACT: Background: Well-designed studies on lifestyle and health-related quality of life (HRQoL) in colorectal cancer survivors based on a bio-psychosocial instead of a traditional biomedical approach are warranted. We report on the applicability of the International Classification of Functioning, Disability and Health (ICF) as useful bio-psychosocial framework to improve research on how lifestyle influences colorectal cancer survivors' HRQoL, using the Energy for life after ColoRectal cancer (EnCoRe) study as an example. Methods: The ICF was used to develop a conceptual model for studying lifestyle and colorectal cancer survivors' HRQoL, by identifying relevant factors from literature and mapping them within the ICF. Subsequently, this model was used for selection of measurement instruments and biomarkers. By linking meaningful concepts within selected measures to the ICF, we could assess the ICF coverage of our developed conceptual model. Results: Within selected measures, 450 meaningful concepts were identified, of which 88% were linked to the ICF. The linking process resulted in 132 distinctive ICF categories assigned (38% within 'Body Functions', 2% within 'Body Structures', 46% within 'Activities and Participation', and 14% within 'Environmental Factors'). Conclusions: The selected EnCoRe study measures broadly cover ICF domains relevant to colorectal cancer survivors, stressing the relevance of using a bio-psychosocial approach for studying this population's HRQoL. Impact: The developed conceptual model will guide data analyses and interpretation, and facilitate early transfer of results for development, evaluation and implementation of personalized multidisciplinary lifestyle interventions. We recommend the ICF as an invaluable framework for improving the quality and scope of HRQoL studies.
    Cancer Epidemiology Biomarkers & Prevention 05/2014; 23(7). DOI:10.1158/1055-9965.EPI-13-1144 · 4.13 Impact Factor
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