Research Laboratories, Fondazione di Ricerca e Cura "Giovanni Paolo II", Catholic University, Campobasso, Italy and National Reference Centre for Familial Hyperlipoproteinemias and Faculty of Nursing and Health Professional Studies, Slovak Medical University, Bratislava, Slovakia.
[Show abstract][Hide abstract] ABSTRACT: Objective
Folate status has been associated with neural tube defects and cerebrovascular disease. We aimed at evaluating possible differences in folate status in two EU Countries and to assess their possible association with dietary patterns and/or other lifestyles.
Methods and Procedures
In the framework of the EU-funded IMMIDIET Project, 1,068 subjects (534 man-woman pairs), aged 26-64 years, were enrolled in Italy and UK. 1-year-recall Food Frequency Questionnaire was used to evaluate dietary intake. Reduced Rank Regression-analysis was used to derive a dietary pattern better describing high dietary folate intake.
11.3% of the Italians and 45.1% of the British exceeded the optimal dietary folate intake of 400μg/day (Recommended Dietary Allowance). 66.7% and 22.1% of Italian and UK women, respectively, all at childbearing age, had folate serum levels lower than 6.62ng/ml (P=0.01). The percentage of total variance of dietary folate intake explained by food group consumption was 14.2% and 16.3% in Italy and UK, respectively. Reduced Rank Regression-analysis indicated a healthy pattern which was positively associated with folate serum levels in both Countries (for all β-coef>0, P<0.001):100μg/day increase in dietary folate intake was associated with 13.8% and 10.5% increase in folate serum levels in the Italian and English population, respectively (for 100μg/day increase eβ-coef=1.138 and 1.105, P<0.001). Smoking habit was negatively but physical activity positively associated with folate serum levels (P<0.05).
An inadequate dietary folate intake and subsequent serum levels were observed in Italian subjects. High consumption of food sources of folate was positively associated with folate serum levels, explaining a good proportion of its variability.
Cell Biochemistry and Function 11/2013; · 2.13 Impact Factor
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