Resting heart rate has been related to the risk of cardiovascular disease and sudden death in several large prospective studies. To investigate prospectively the association of novel heart rate parameters and of carotid artery stiffness with sudden death and other cardiovascular disease. The Paris Prospective Study III (PPS3) is a new, ongoing French prospective study. From June 2008 to December 2011, 10,000 men and women aged 50-75 years who will have a preventive medical check-up at the Centre d'Investigations Préventives et Cliniques in Paris (France), will be enrolled in the study, after signing an informed consent. In addition to the general health examination, each subject's heart rhythm will be recorded during the course of the health check-up (approximately 2(1/2) h) and an echo-tracking of the right carotid bulb will be performed by trained technicians. A bio bank and DNA bank will be established for further biomarker and genetic analyses. The occurrence of cardiovascular disease including acute coronary syndrome, stroke, peripheral artery disease and sudden death, and of mortality, of the participants will be followed up during 20 years. With an estimated mean annual rate of sudden death of 0.1% and its increasing incidence rate with age, between 250 and 300 sudden deaths are expected. This unique study should provide new insights into the regulation of heart rate and blood pressure and should enable to identify novel heart rate parameters that are associated with sudden death.
"The necessity of research on the etiology and prognosis of heart disease has been obvious for many decades. This has resulted in countless epidemiological studies with a focus on CHD or CVD at large, which is represented by the recent cardiovascular research presented in EJE [58–74]. However, multiple, and sometimes inconsistent, definitions of cardiac outcomes are in use. "
[Show abstract][Hide abstract] ABSTRACT: The prevalence of cardiovascular diseases is rising. Therefore, adequate risk prediction and identification of its determinants is increasingly important. The Rotterdam Study is a prospective population-based cohort study ongoing since 1990 in the city of Rotterdam, The Netherlands. One of the main targets of the Rotterdam Study is to identify the determinants and prognosis of cardiovascular diseases. Case finding in epidemiological studies is strongly depending on various sources of follow-up and clear outcome definitions. The sources used for collection of data in the Rotterdam Study are diverse and the definitions of outcomes in the Rotterdam Study have changed due to the introduction of novel diagnostics and therapeutic interventions. This article gives the methods for data collection and the up-to-date definitions of the cardiac outcomes based on international guidelines, including the recently adopted cardiovascular disease mortality definitions. In all, detailed description of cardiac outcome definitions enhances the possibility to make comparisons with other studies in the field of cardiovascular research and may increase the strength of collaborations.
European Journal of Epidemiology 03/2012; 27(3):173-85. DOI:10.1007/s10654-012-9668-8 · 5.34 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over a 1,000 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.
European Journal of Epidemiology 08/2011; 26(8):657-86. DOI:10.1007/s10654-011-9610-5 · 5.34 Impact Factor
Allan Linneberg, Rikke K Jacobsen, Tea Skaaby, Amy E Taylor, Meg E Fluharty, Jørgen L Jeppesen, Johan H Bjørngaard, Bjørn O Åsvold, Maiken E Gabrielsen, Archie Campbell, [...], Blair H Smith, Caroline Hayward, Thorkild I A Sørensen, Betina H Thuesen, Naveed Sattar, Richard W Morris, Pål R Romundstad, Marcus R Munafò, Marjo-Riitta Jarvelin, Lise Lotte N Husemoen
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