Pulmonary arterial hypertension associated with connective tissue disease and immunosuppressive therapy.
Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine.Circulation Journal (Impact Factor: 3.58). 10/2011; 75(11):2543-4. DOI: 10.1378/chest.130.1.182
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ABSTRACT: Pulmonary arterial hypertension is a group of diseases which forms a small subset of those with elevated pulmonary artery pressure (pulmonary hypertension). The recent development of selective pulmonary vasodilator has lead to a substantial resurgence of interest in what have been previously regarded as rare and incurable diseases. This review aims to describe the spectrum of pulmonary vascular diseases, the evolving understanding as to pathogenesis, the evolving evidence of efficacy for drug therapies, trying to put this into a contemporary Australian context. Several key pathogenic pathways may be involved: prostacycline, Nitric Oxide-cGMP-phosphodiesterase 5 and endothelin- all of which are exploited for therapeutic benefit by newly available drug therapies. A recently modified classification system reasserts the importance of precise diagnosis. The cardinal symptom of exertional dyspnea warrants careful evaluation in an attempt to prevent (frequently occurring) substantial delay in diagnosis. Echocardiogram is the cornerstone of screening for pulmonary arterial hypertension; however, a detailed evaluation including a carefully performed right heart catheterisation with sufficient data to allow calculation of pulmonary vascular resistance is key to accurate diagnosis. These new approaches to therapy are already substantially improving quality of life and prognosis.Internal Medicine Journal 02/2007; 37(1):38-48. · 1.82 Impact Factor
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ABSTRACT: The catalytic properties of VOx/TiO2 when coated as a thin layer on stainless steel plates figuring out the walls of a reactor were studied in the oxidative dehydrogenation of propane to propene. The method to obtain mechanically stable but catalytically active and selective coatings consisted of dip-coating plates in titanium oxide suspension, followed by grafting of oxovanadium precursor specie in various amounts. In that way the textural and structural properties of coated plates were very similar to those of VOx/TiO2 powders of the same composition as seen from Raman and XPS experiments. The catalytic properties were investigated in a specially designed plate reactor and compared to those of the same catalyst used as powders in a conventional fixed bed reactor. The lower activity of plates vs. powders for the same composition and amount of active phase was attributed to the negative role played by iron diffusing towards the surface and poisoning the vanadate specie.Applied Catalysis A-general - APPL CATAL A-GEN. 01/2011; 391(1):43-51.
- Value in Health 01/2010; 13(3). · 2.19 Impact Factor
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