"MRI-negative PET-positive" temporal lobe epilepsy: Invasive EEG findings, histopathology, and postoperative outcomes

Brno Epilepsy Centre, First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Epilepsy & Behavior (Impact Factor: 2.26). 09/2011; 22(3):537-41. DOI: 10.1016/j.yebeh.2011.08.019
Source: PubMed


The aim of this retrospective study was to analyze invasive EEG findings, histopathology, and postoperative outcomes in patients with MRI-negative, PET-positive temporal lobe epilepsy (TLE) (MRI-/PET+TLE) who had undergone epilepsy surgery. We identified 20 patients with MRI-/PET+TLE (8.4% of all patients with TLE who had undergone surgery; 11 men, 9 women). Of the 20 patients, 16 underwent invasive EEG. The temporal pole and hippocampus were involved in the seizure onset zone in 62.5% of the patients. We did not identify a lateral temporal or extratemporal seizure onset in any patient. Of the 20 patients, 17 had follow-up periods >1 year (mean follow-up=3.3 years). At the final follow-up, 70.6% patients were classified as Engel I, 5.8% of patients as Engel II, and 11.8% of patients as Engel III and IV (11.8%). Histopathological evaluation showed no structural pathology in any resected hippocampus in 58% of all evaluated temporal poles. The most common pathology of the temporal pole was focal cortical dysplasia type IA or IB. MRI-/PET+TLE should be delineated from other "nonlesional TLE." The ictal onset in these patients was in each case in the temporal pole or hippocampus, rather than in the lateral temporal neocortex. Standard surgery produced a good postoperative outcome, comparable to that for patients with lesional TLE. Histopathological findings were limited: the most common pathology was focal cortical dysplasia type I.

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    • "FDG PET is useful in patients with nonlesional mTLE. These “MRI negative PET positive cases” are quite different than nTLE even though they may have a cortical lesion [68]. One group did a quantitative parametric analysis on 133 scans of 35 patients with nTLE with confirmed pathology [69]. "
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    ABSTRACT: Complex partial seizures (CPSs) can present with various semiologies, while mesial temporal lobe epilepsy (mTLE) is a well-recognized cause of CPS, neocortical temporal lobe epilepsy (nTLE) albeit being less common is increasingly recognized as separate disease entity. Differentiating the two remains a challenge for epileptologists as many symptoms overlap due to reciprocal connections between the neocortical and the mesial temporal regions. Various studies have attempted to correctly localize the seizure focus in nTLE as patients with this disorder may benefit from surgery. While earlier work predicted poor outcomes in this population, recent work challenges those ideas yielding good outcomes in part due to better localization using improved anatomical and functional techniques. This paper provides a comprehensive review of the diagnostic workup, particularly the application of recent advances in electroencephalography and functional brain imaging, in neocortical temporal lobe epilepsy.
    07/2012; 2012:103160. DOI:10.1155/2012/103160
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    ABSTRACT: Primary- and secondary MR findings, volumetric measurements and MR spectroscopy data of each hippocampus represent more a dozen of variables that radiologists should consider in a quantitative MR report of temporal lobe epilepsy (TLE). There is a paucity of data about the significance of secondary MR findings simultaneously evaluated with volumetry and MR spectroscopy. We analyzed the influence of qualitative-secondary MR findings simultaneously with quantitative (volumetry and spectroscopy) data in MRI positive- and negative patients with mesial temporal sclerosis (MTS). Analytic and transversal study of 59 patients with TLE and suspiciousness of MTS. 13 variables were analyzed for each hippocampus: age, gender, cerebral hemisphere, temporal lobe atrophy, choroidal fissure dilatation, mamillary body atrophy, collateral white matter atrophy, fornix asymmetry; Naa/Cr, Cho/Cr, mI/Cr, Naa/(Cr+Cho); and hippocampus volume (mm3). Multivariate discriminant analysis (DA) was performed with the aim to identify specific morphologic and metabolic attributes in hippocampi with and without MTS. Discriminant function significantly differentiated the hippocampi with- and without MTS (Wilks' λ = 0.211, χ2 (11) = 116.072, p = < .001. The model explained 79.03% of the variation in the grouping variable. The pooled within-groups correlations showed the highest influence of discriminating function for the secondary MR findings over metabolite indices and hippocampal volumes, the overall predictive accuracy was 93.9%. Due of the large number of variables (qualitative and quantitative) to which a radiologist is exposed in a conventional hippocampal MR-report, such evaluation might benefit from the use of predictive models generated by unconventional statistical methods, such as DA.
    Schweizerische medizinische Wochenschrift 06/2012; 142:w13549. DOI:10.4414/smw.2012.13549 · 2.09 Impact Factor
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    ABSTRACT: Purpose: This study aims to investigate the contributions of magnetoencephalography (MEG) in magnetic resonance imaging (MRI)-negative patients. Methods: A total of 18 MRI-negative patients diagnosed with refractory epilepsy, subjected to MEG investigation, and subsequently underwent surgery were selected for retrospective analysis. A 1.5-tesla Magnetom Sonata with an eight-channel head array coil was used. MEG data were obtained using a 74/248-channel system. Results: A total of 16 patients (16/18) had positive MEG results, comprising 12 patients with monofocal localizations, five with multifocal localizations, and one with unremarkable results in MEG. In addition, 12 patients had indicative single photon-emission computed tomography (SPECT), five had indicative fluorodeoxyglucose positron emission tomography (FDG-PET), and all the patients had intracranial electroencephalography (EEG) (14 with subdural electrodes and four with electrocorticography). The intracranial EEG recordings of nine patients were guided by MEG informative results. Among these 18 patients, 10 exhibited good postoperative outcomes (Engel I and II), four of which were completely seizure-free. All these ten patients had clear monofocal localization in MEG, including nine with accordant indicative metabolic changes in either SPECT or FDG-PET, or both. None of the five patients with multifocal localizations achieved good postoperative outcomes. Conclusion: For cases with negative MRI findings, epilepsy surgery may be an alternative option for pharmaco-resistant patients if epileptogenic focus localizations by MEG are present in multimodal evaluation.
    Acta Neurologica Scandinavica 08/2012; 127(4). DOI:10.1111/j.1600-0404.2012.01712.x · 2.40 Impact Factor
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