Article

Heterogenous mechanisms of mild cognitive impairment in Parkinson's disease.

Institute of Clinical Neurobiology, Vienna, Austria.
Acta Neurovegetativa (impact factor: 2.73). 09/2011; 119(3):381-2. DOI:10.1007/s00702-011-0716-4 pp.381-2
Source: PubMed

ABSTRACT Mild cognitive impairment in Parkinson disease (PD-MCI) shows heterogeneity in the clinical presentation, neuropsychology, neuroimaging, and neuropathology, suggesting abnormal metabolic network activities involving several cortical and subcortical systems. Prospective studies using specific biomarkers, including amyloid imaging and CSF biomarkers are important for the diagnosis and prognostic assessment of early cognitive deficits in PD patients.

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Keywords

abnormal metabolic network activities
 
amyloid imaging
 
clinical presentation
 
Mild cognitive impairment
 
neuroimaging
 
neuropathology
 
Parkinson disease
 
PD patients
 
PD-MCI
 
prognostic assessment
 
Prospective studies
 

Kurt Jellinger