Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci

Department of Pharmacology, University of Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences (Impact Factor: 0.68). 10/2011; 24(4):565-70.
Source: PubMed

ABSTRACT Garlic has been used safely since ancient times as both food and medicine in human populations, but studies of its efficacy in the management of diabetes have yielded conflicting results. This study has evaluated the potential hypoglycemic effects of garlic in type 2 diabetic patients. The study was conducted in diagnosed type 2 diabetic patients (n=60) with fasting blood sugar level above 126 mg/dl to evaluate the effects of adding garlic tablets with standard antidiabetic therapy on blood sugar. Patients were divided randomly into 2 groups. Group 1 (n=30) was given tablet Garlic (KWAI) 300 mg thrice daily + Metformin 500 mg twice daily and Group 2 (n=30) was given Placebo+Metformin 500 mg twice daily respectively for 24 weeks. Serum lipids and fasting blood glucose were measured at week 0, 12 and week 24. Group1 showed significant reduction in fasting blood sugar at week 24 with a percentage decrease of (-3.12 percent) (P = <0.005) as compared to group 2 (0.59 percent). At the end of week 24, GR1 group also showed considerable decrease in mean total cholesterol (6.2 mg/dl, -2.82%, P=<0.005), LDL-C (-3 mg/dl, 2.18% P=<0.005), triglycerides (-5.2 mg/dl, 3.12%, P<0.005) while HDL cholesterol was significantly increased (2.36 mg/dl, 6.72%, P<0.005) as compared to GR2 group. Combination of garlic with typical antidiabetic remedy has shown to improve glycemic control in addition to antihyperlipidemic activity. Garlic may be a good addition in the management of patients with diabetes and hyperlipidemia.

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    • "This overproduction occurs under hyperglycemic conditions because the number of substrates entering the Krebs cycle is greatly increased, and consequently, the number of reducing equivalents donating electrons to the mitochondrial electron transport chain is also increased [8]. Therefore, antioxidant compounds such as tea catechins, resveratrol, and garlic acid have been demonstrated to have benefits in the prevention and treatment of diabetic complications caused by oxidative stress [10] [11] [12]. The seeds of Bixa orellana L., a native shrub from tropical America, are a rich source of antioxidant carotenoid pigments that are largely used by the food coloring industry. "
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    ABSTRACT: The present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days in the following groups: nondiabetic control, diabetic vehicle, diabetic 10 mg/kg BIX, diabetic 100 mg/kg BIX, diabetic 10 mg/kg NBIX, diabetic 100 mg/kg NBIX, diabetic metformin, and diabetic insulin. Blood glucose, LDL cholesterol, and triglyceride levels were reduced in the diabetic rats treated with BIX. BIX treatment prevented protein oxidation and nitric oxide production and restored superoxide dismutase activity. NBIX treatment did not change most parameters assessed, and at the highest dose, it increased LDL cholesterol and triglycerides levels and showed prooxidant action (increased protein oxidation and nitric oxide levels). These findings suggested that BIX could have an antihyperglycemic effect, improve lipid profiles, and protect against damage induced by oxidative stress in the diabetic state. Because NBIX is a water-soluble analog of BIX, we propose that lipophilicity is crucial for the protective effect of annatto carotenoids against streptozotocin-induced diabetes.
    International Journal of Endocrinology 01/2014; 2014(5):839095. DOI:10.1155/2014/839095 · 1.95 Impact Factor
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    • "The diabetic always suffered from hyperlipidemia and hypertension at the same time. So, antilipemic medicine was also used in the therapy to prevent and treat the cardiovascular disease caused by hyperlipidemia [26]. In this meta-analysis, we found that the bariatric surgery could reduce triglycerides and raise HDL, which was highly favorable to reduce the cardiovascular risks for the type 2 diabetes. "
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    ABSTRACT: Objective: To assess the effects of bariatric surgery versus medical therapy for type 2 diabetes mellitus. Methods: The Cochrane library, PubMed, Embase, Chinese biomedical literature database, and Wanfang database up to February 2012 were searched. The literature searches strategies contained terms ("diabetes*", "surg*", and "medic*" were used), combined with the medical subject headings. Randomized controlled trails (RCTs) of frequently used bariatric surgery for obese patients with type 2 diabetes were included. Study selection, data extraction, quality assessment, and data analyses were performed according to the Cochrane standards. Results: Three randomized controlled trials (RCTs) involving 170 patients in the bariatric surgery groups and 100 patients in the medical therapy group were selected. Compared with medical therapy, bariatric surgery for type 2 diabetes can significantly decrease the levels of HbA1c, FBG, weight, triglycerides, and the dose of hypoglycemic, antihypertensive, and lipid-lowering medicine, while increasing the rate of diabetes remission (RR = 9.74, 95%CI, (1.36, 69.66)) and the levels of high-density lipoprotein. However, there are no statistical differences in serious adverse events between the surgical and medical groups (RR = 1.23, 95%CI, (0.80, 1.87)). Conclusions: Surgical procedures were more likely to help patients achieve benefits than medical therapy alone. Further intensive RCTs of high-quality, multiple centers and long-term followup should be carried out to provide more reliable evidence.
    07/2013; 2013(11):410609. DOI:10.1155/2013/410609
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    • "It has had ethnic diversity and this influences CAM use as well. Uses of herbs [41] like bitter gourd [42-44], Misai Kucing (Orthosiphon Stamineus Benth) [45,46], garlic (Allium Sativum) [47,48], and ginseng (Panax Ginseng) [49] are believed to reduce blood sugar levels. Bitter gourd [50], also known as Momordica Charantia is a tropical vine that is widely believed to bring down blood sugar levels, despite a lack of robust evidence [43,44,50-52]. "
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    BMC Complementary and Alternative Medicine 06/2013; 13(1):148. DOI:10.1186/1472-6882-13-148 · 2.02 Impact Factor
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