Article

Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients.

Department of Pharmacology, University of Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences (Impact Factor: 0.95). 10/2011; 24(4):565-70.
Source: PubMed

ABSTRACT Garlic has been used safely since ancient times as both food and medicine in human populations, but studies of its efficacy in the management of diabetes have yielded conflicting results. This study has evaluated the potential hypoglycemic effects of garlic in type 2 diabetic patients. The study was conducted in diagnosed type 2 diabetic patients (n=60) with fasting blood sugar level above 126 mg/dl to evaluate the effects of adding garlic tablets with standard antidiabetic therapy on blood sugar. Patients were divided randomly into 2 groups. Group 1 (n=30) was given tablet Garlic (KWAI) 300 mg thrice daily + Metformin 500 mg twice daily and Group 2 (n=30) was given Placebo+Metformin 500 mg twice daily respectively for 24 weeks. Serum lipids and fasting blood glucose were measured at week 0, 12 and week 24. Group1 showed significant reduction in fasting blood sugar at week 24 with a percentage decrease of (-3.12 percent) (P = <0.005) as compared to group 2 (0.59 percent). At the end of week 24, GR1 group also showed considerable decrease in mean total cholesterol (6.2 mg/dl, -2.82%, P=<0.005), LDL-C (-3 mg/dl, 2.18% P=<0.005), triglycerides (-5.2 mg/dl, 3.12%, P<0.005) while HDL cholesterol was significantly increased (2.36 mg/dl, 6.72%, P<0.005) as compared to GR2 group. Combination of garlic with typical antidiabetic remedy has shown to improve glycemic control in addition to antihyperlipidemic activity. Garlic may be a good addition in the management of patients with diabetes and hyperlipidemia.

5 Followers
 · 
671 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days in the following groups: nondiabetic control, diabetic vehicle, diabetic 10 mg/kg BIX, diabetic 100 mg/kg BIX, diabetic 10 mg/kg NBIX, diabetic 100 mg/kg NBIX, diabetic metformin, and diabetic insulin. Blood glucose, LDL cholesterol, and triglyceride levels were reduced in the diabetic rats treated with BIX. BIX treatment prevented protein oxidation and nitric oxide production and restored superoxide dismutase activity. NBIX treatment did not change most parameters assessed, and at the highest dose, it increased LDL cholesterol and triglycerides levels and showed prooxidant action (increased protein oxidation and nitric oxide levels). These findings suggested that BIX could have an antihyperglycemic effect, improve lipid profiles, and protect against damage induced by oxidative stress in the diabetic state. Because NBIX is a water-soluble analog of BIX, we propose that lipophilicity is crucial for the protective effect of annatto carotenoids against streptozotocin-induced diabetes.
    International Journal of Endocrinology 01/2014; 2014:839095. DOI:10.1155/2014/839095 · 1.52 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Phytochemical investigations on the chloroform soluble fraction of the whole plant of Withania somnifera led to the isolation of 20β hydroxy-1-oxo(22R)-witha-2,5,24 trienolide 1, (20R, 22R-14α, 20α)-dihydroxy-1-oxowitha-2,5,16,24 tetraenolide 2, and (20R, 22R)-1-oxo-5α, 8β-dihydroxywitha-6α, 7β-epoxide-2,24-dienolide (withasomilide) 3. The structures of these compounds were confirmed through spectral studies in comparison with data in the literature. These isolated compounds (1–3) exhibited potent inhibition against α-glucosidase with IC50 values of 98.60, 38.20, and 40.65 μg/ml respectively.
    Medicinal Chemistry Research 05/2013; 23(5). DOI:10.1007/s00044-013-0838-3 · 1.61 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Diabetes shows a wide range of variation in prevalence around the world and it is expected to affect 300 million by the year 2025. In a prevention framework where banning policies and educational strategies lead the interventions, functional foods (FFs) with their specific health effects could, in the future, indicate a new mode of thinking about the relationships between food and health in everyday life. Functional ingredients, such as stevioside, cinnamon, bitter melon, garlic and onion, ginseng, Gymnema sylvestre and fenugreek, have been addressed for their specific actions towards different reactions involved in diabetes development. New strategies involving the use of FF should be validated through large-scale population trials, considering validated surrogate end points to evaluate the effect of FF in prevention of chronic diseases such as type 2 diabetes mellitus.
    International Journal of Food Sciences and Nutrition 11/2011; 63 Suppl 1:51-61. DOI:10.3109/09637486.2011.637487 · 1.20 Impact Factor