Curcumin nanoformulations: A future nanomedicine for cancer

Cancer Biology Research Center, Sanford Research/University of South Dakota, 2301 E. 60th Street North, Sioux Falls, SD 57104, USA.
Drug discovery today (Impact Factor: 6.69). 09/2011; 17(1-2):71-80. DOI: 10.1016/j.drudis.2011.09.009
Source: PubMed

ABSTRACT Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer potential. In this review, we focus on the design and development of nanoparticles, self-assemblies, nanogels, liposomes and complex fabrication for sustained and efficient curcumin delivery. We also discuss the anticancer applications and clinical benefits of nanocurcumin formulations. Only a few novel multifunctional and composite nanosystem strategies offer simultaneous therapy as well as imaging characteristics. We also summarize the challenges to developing curcumin delivery platforms and up-to-date solutions for improving curcumin bioavailability and anticancer potential for therapy.

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    • "The encapsulation of bioactive compounds represents an efficient strategy to improve their dispersibility in foods, to prevent their degradation under adverse environmental conditions , such as extreme pH and temperature, light exposure, presence of reactive oxygen species, to minimize the interaction with other food ingredients, as well as to promote their bioaccessibility and bioavailability (Ahmed et al., 2012; Yu et al., 2012; Yu and Huang, 2012; Yallapu et al., 2012). Moreover, the development of a better understanding of the correlation between particle structure and behavior in product and in body, is increasingly becoming an enabling tool for controlling the release of the encapsulated bioactives at target sites, for improving food compatibility, as well as for masking unpleasant tastes and flavors of food additives through tailored carrier Contents lists available at ScienceDirect "
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    ABSTRACT: Submicrometric lipid-based carriers were developed to encapsulate curcumin and deliver it to intestinal epithelial cells. A lipid matrix comprising monoolein, sunflower oil and water at weight ratio 1:1:1 was selected, upon screening of different combinations of amphiphilic molecules, vegetable oils and water, because of its high encapsulations efficiency of curcumin, retained over time and relatively lower content of amphiphilic molecules. Upon dispersion in aqueous phase, the carriers were stabilized by: (a) whey protein isolates (WPI), alone and (b) in combination with modified starch (WPI-MS), or by (c) polysorbate 20 (T20). Whereas T20-stabilized systems exhibited extremely fine particles (120nm), WPI and WPI-MS stabilized carriers were characterized by a significantly larger mean particle size (270nm). The thicker macromolecular layer of WPI and WPI-MS enabled better (a) physical stability, (b) controlled shell degradation during simulated digestion, and (c) curcumin bioaccessibility targeted at the intestinal digestion phase than T20-systems. However, uptake studies in HT29 cell lines, simulating intestinal epithelial cells, showed that WPI and WPI-MS carriers exhibited after 24h a lower relative uptake than T20-stabilized systems (about 60 % and 80 %, respectively), as a consequence of smaller size and higher cell adherence of T20 carriers to the cell membrane. Copyright © 2015. Published by Elsevier B.V.
    International Journal of Pharmaceutics 08/2015; 494(1). DOI:10.1016/j.ijpharm.2015.08.039 · 3.65 Impact Factor
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    • "To overcome these delivery obstacles, different nanoscale delivery systems including liposomes (Narayanan et al., 2009; Tavano et al., 2014), nanostructured lipid carriers (Wu et al., 2010), nanoemulsions, polymeric micelles and polymeric nanoparticles (Coradini et al., 2014; Detoni et al., 2012; Yallapu et al., 2012) have been described as strategies to improve the bioavailability, the pharmacological efficacy as well as the limited photostability of these polyphenols. Among these nanocarriers, special interest has been aroused on developing polymeric nanoparticles, either as solid spheres or capsules, based on biodegradable and biocompatible materials (Mora-Huertas et al., 2010). "
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    ABSTRACT: Polyphenols, which are secondary plant metabolites, gain increasing research interest due to their therapeutic potential. Among them, resveratrol and curcumin are two agents showing antioxidant, anti-inflammatory, antimicrobial as well as anticarcinogenic effects. In addition to their individual therapeutic effect, increased activity was reported upon co-delivery of the two compounds. However, due to the poor water solubility of resveratrol and curcumin, their clinical application is currently limited. In this context, lipid-core nanocapsules (LNC) composed of an oily core surrounded by a polymeric shell were introduced as drug carrier systems with the potential to overcome this obstacle. Furthermore, the encapsulation of polyphenols into LNC can increase their photostability. As the attributes of the polyphenols make them excellent candidates for skin treatment, the aim of this study was to investigate the effect of co-delivery of resveratrol and curcumin by LNC upon topical application on excised human skin. In contrast to the formulation with one polyphenol, resveratrol penetrated into deeper skin layers when the co-formulation was applied. Based on vibrational spectroscopy analysis, these effects are most likely due to interactions of curcumin and the stratum corneum, facilitating the skin absorption of the co-administered resveratrol. Furthermore, the interaction of LNC with primary human skin cells was analyzed encountering a cellular uptake within 24h potentially leading to intracellular effects of the polyphenols. Thus, the simultaneous delivery of resveratrol and curcumin by LNC provides an intelligent way for immediate and sustained polyphenol delivery for skin disease treatment. Copyright © 2015. Published by Elsevier B.V.
    European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences 07/2015; 78. DOI:10.1016/j.ejps.2015.07.018 · 3.35 Impact Factor
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    • "The nanocurcumin aqueous dispersion had an antimicrobial effect stronger than the curcumin (Bhawana et al., 2011). Studies have been approaching different nanocurcumin formulations with technological potential to improve its bioavailability to treat diseases such as cancer (Yallapu et al., 2012). Nanotechnology has become multidisciplinary in the field of technology and applied sciences; it involves the study of nanoparticles and the capacity of working with different materials in nanometric scale in order to understand, create, characterize and use materials with new properties derived from their nanostructures (Azeredo, 2009). "
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    ABSTRACT: Curcumin is a powerful bioactive agent and natural antioxidant, but it is practically water-insoluble and has low bioavailability; a possible solution to this obstacle would be formulations of curcumin nanoparticles. Surfactants such as tween 80 can be used to stabilize low-solubility molecules preventing particle aggregation. The objectives of this study were the preparation of a suspension with curcumin nanoparticles in tween 80, the testing of pure curcumin solubility and of a simple mixture of curcumin with tween 80 and nanosuspension in water and ethanol as solvents, and finally the assessment of the antioxidant activity. We prepared the nanosuspension by injecting a curcumin solution in dichloromethane at low flow in water with tween 80 under heating and ultrasound. The analysis of particles size was conducted through dynamic light scattering; the non-degradation of curcumin was verified through thin-layer chromatography. The analyses of antioxidant activity were carried out according to the DPPH method. The method applied to reduce the particles size was efficient. Both the curcumin suspension and nanosuspension in tween 80 increased its solubility. Curcumin and the formulations presented antioxidant activity.
    03/2015; 35(1):115-119. DOI:10.1590/1678-457X.6515
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