Protein Degradation: BAGging Up the Trash

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Current biology: CB (Impact Factor: 9.92). 09/2011; 21(18):R692-5. DOI: 10.1016/j.cub.2011.08.018
Source: PubMed

ABSTRACT Cells efficiently uncover and degrade proteins that are misfolded. However, we know very little about what cells do to protect themselves from mislocalized proteins. A new study reveals a novel quality control pathway that recognizes and degrades secretory pathway proteins that have failed to target to the endoplasmic reticulum.

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