We present a case of a late-preterm infant admitted for suspected cyanotic heart disease who was found to have a thrombosed ductus arteriosus. Maternal history was significant for heterozygosity for Factor V Leiden, treated with enoxaparin during her pregnancy, and congenital hearing loss. The neonate did not have a Factor V Leiden mutation detected, but was found to have a heterozygous mutation within the MFTHR gene. He was treated with anticoagulation, with improving hemodynamics measured by echocardiogram. This case presents a rare disease, which is potentially fatal if diagnosis is delayed.
[Show abstract][Hide abstract] ABSTRACT: Spontaneous neonatal arterial thrombosis is rare in the neonatal period. Four cases of neonatal arterial thrombosis presenting with suspected congenital heart disease are reported. The urgency for a correct diagnosis in this setting and the need for active treatment for a remediable condition are emphasised. These treatment options are discussed.
Archives of Disease in Childhood - Fetal and Neonatal Edition 02/2007; 92(1):F59-61. DOI:10.1136/adc.2005.091850 · 3.12 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Neonatal aortic thrombosis is a rare occurrence, but can be fatal. Treatment of this condition is hampered by the lack of large studies involving this pediatric population. Reporting of this condition is also not standardized.
The purpose of this review is to collate available literature on the incidence, risk factors, presentation, treatment and outcome of neonatal aortic thrombosis as well as suggest a treatment model.
A Medline search of PubMed, OVID and Cochrane databases was undertaken using the key words "neonatal", "infant", "aorta", "aortic", "thrombosis", "thrombus" and "clot". Limits were set for articles that were English language only and published between 1980 and September 2009. Following review of all articles using predetermined search words and criteria, 38 were found with sufficient data for our purpose. The reported total number of neonatal patients with aortic thrombosis was 148 and 78% of the aortic thromboses in this review were related to arterial umbilical catheterization.
We have suggested a classification system to standardize reporting of neonatal aortic thrombosis, as well as a treatment decision tree, and a clinical guide for the treatment of thrombosis in children. As always, clinicians should balance the risks and benefits of their decision to treat with the level of local expertise. This guide may specifically serve the neonatal population with line-related aortic thrombosis.
[Show abstract][Hide abstract] ABSTRACT: In the course of some 800 perinatal necropsies (corresponding to approximately 26,000 deliveries), 3 stillborn infants were found to have an almost completely closed ductus arteriosus. Each of these showed cardiomegaly, dilatation of right-side chambers, pulmonary hyperaemia and oedema of varying degree and extent; intrauterine death was considered to be due to P.C.D.A. In several further cases the ductus was also narrowed but not necessarily responsible for intrauterine death. This frequency suggests that P.C.D.A. is more common than might be surmised from very scanty documentation in the literature. Possible aetiological factors of P.C.D.A. as well as its effects on the circulation are briefly discussed.
Early Human Development 05/1978; 2(1):15-23. DOI:10.1016/0378-3782(78)90049-X · 1.79 Impact Factor
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