Adaptive servo-ventilation improves renal function in patients with heart failure

Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondoh 1-1-1, Akita 010-8543, Japan.
Respiratory medicine (Impact Factor: 3.09). 09/2011; 105(12):1946-53. DOI: 10.1016/j.rmed.2011.09.001
Source: PubMed


Impaired cardiac function and sleep-disordered breathing (SDB) are associated with progression of chronic kidney disease (CKD) in heart failure (HF) patients. Adaptive servo-ventilation (ASV) therapy improves cardiac function in HF patients regardless of the SDB severity through hemodynamic support and prevention of repetitive hypoxic stress. This study was designed to test the hypothesis that ASV therapy improves renal function in HF patients with SDB.
Of 59 consecutively enrolled HF patients, 43 with moderate-to-severe SDB underwent ASV therapy. HF patients were divided into the ASV-treated group (n = 27) and the non-ASV-treated group (n = 16). Estimated glomerular filtration rate (eGFR), echocardiographic parameters, and inflammatory biomarkers were measured before and 12 months after ASV initiation. Improvement in the eGFR was found in the ASV-treated group, but not in the non-ASV-treated group. There was a positive correlation between the increases in eGFR and left ventricular ejection fraction (r = 0.488, p = 0.001). The changes in high-sensitivity C-reactive protein were negatively correlated with change in the eGFR (r = -0.416, p = 0.006).
ASV therapy could improve renal dysfunction in HF patients through hemodynamic support. Additionally, prevention of SDB with the use of ASV therapy could exert anti-inflammatory effects, which could contribute to the improvement of renal function in HF patients.

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Available from: Hiroyuki Watanabe, Sep 23, 2015
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    • "We previously showed that short-duration ASV can be an alternative approach for HF patients who cannot tolerate longduration ASV therapy [9]. Hemodynamic improvements by ASV therapy are produced immediately in HF patients [19]. "
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    ABSTRACT: Background Short-duration adaptive servo-ventilation (ASV) therapy can be effective for heart failure (HF) patients. Albuminuria is recognized as a prognostic marker for HF. We investigated whether short-duration and short-term ASV therapy reduced albuminuria in HF patients. Methods and results Twenty-one consecutive HF patients were divided into two groups: those who tolerated ASV therapy (ASV group, n = 14) and those who did not (non-ASV group, n = 7). ASV therapy was administered to enrolled patients for 1 week for 2 h per day (1 h in the morning and 1 h in the afternoon). The urinary albumin to creatinine ratio (UACR), urinary 24 h norepinephrine (NE) excretion, high-sensitivity C-reactive protein (hs-CRP), and plasma brain natriuretic peptide (BNP) levels were measured before and 1 week after ASV therapy. In the ASV group, but not the non-ASV group, the UACR significantly decreased, together with a decrease in urinary NE and hs-CRP levels. There were significant correlations between the changes in UACR and hs-CRP and between the changes in urinary NE and hs-CRP. Multiple linear regression analyses indicated that ASV use was the strongest predictor of decreased UACR. Conclusion Albuminuria, urinary NE, and hs-CRP levels reduced in HF patients who could receive short-duration and short-term ASV therapy. Anti-inflammatory effects of ASV therapy may partly mediate the reduction of albuminuria.
    Journal of Cardiac Failure 10/2014; 65(5). DOI:10.1016/j.jjcc.2014.07.008 · 3.05 Impact Factor
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    • "Since its introduction in 2001, many case series, case control series, and randomized controlled trials (RCT) have been published with considerable improvement in AHI, left ventricular ejection fraction (LVEF), and quality of life with volume-targeted [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] and flow-targeted devices [14] [15] [16] [17] [18] [19] in patients with pure CSR. It was found that even patients with mild to moderate sleep disordered breathing (SDB) can demonstrate a significant improvement in LVEF [12] [13]. Very few randomized controlled trials of ASV versus CPAP in chronic heart failure have been published [7], while two meta-analyses are available that are in favor for a significant reduction in AHI and improvement in LVEF by ASV [20] [21]. "
    Sleep Medicine 08/2014; 15(8). DOI:10.1016/j.sleep.2014.04.006 · 3.15 Impact Factor
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