Article

Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models.

Department of Medicine, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB 701, Miami, FL 33136, USA.
Breast Cancer Research and Treatment (impact factor: 4.43). 09/2011; 131(1):321-4. DOI:10.1007/s10549-011-1784-8 pp.321-4
Source: PubMed

ABSTRACT Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue.

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Keywords

associated stromal tissue
 
dual-species microarray analysis method
 
gene expression alterations
 
gene expression profiles
 
Illumina gene expression beadchips
 
limited interspecies cross-hybridization
 
simultaneous genome-wide analysis
 
stromal gene expression profiles
 
understanding tumor biology
 
xenograft models