Article

Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components.

Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.
Bioorganic & medicinal chemistry letters (impact factor: 2.65). 09/2011; 21(21):6293-6. DOI:10.1016/j.bmcl.2011.08.122 pp.6293-6
Source: PubMed

ABSTRACT The design and synthesis of dehydroxymethylepoxyquinomicin (DHMEQ) derivatives were carried out to investigate the intracellular targets. The synthetic biotin probe exhibited membrane permeability and combined selectively with the target protein p65.

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Keywords

synthetic biotin probe exhibited membrane permeability
 

Tsuyoshi Saitoh