Article

Wnt Signaling as a Potential Therapeutic Target for Frontotemporal Dementia

Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA.
Neuron (Impact Factor: 15.98). 09/2011; 71(6):955-7. DOI: 10.1016/j.neuron.2011.09.002
Source: PubMed

ABSTRACT Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.

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