Article

Vaccines for colorectal cancer and renal cell carcinoma.

Division of Hematology & Oncology and Rush University Cancer Center, Rush University Medical Center, Chicago, IL, USA.
The Cancer Journal (impact factor: 3.26). 09/2011; 17(5):283-93. DOI:10.1097/PPO.0b013e318232ff44 pp.283-93
Source: PubMed

ABSTRACT Vaccines have shown promise for the prevention and treatment of solid tumors. Colorectal cancer and renal cell carcinoma are common malignancies that may be amenable to vaccine strategies. This review summarizes target antigens in colorectal and renal cell carcinoma, discusses some of the vaccine approaches in development, and details the results of pivotal phase III trials evaluating therapeutic vaccines in patients with advanced colorectal and renal cell carcinoma. Finally, some of the challenges with vaccine development for colorectal and renal cell carcinoma are described.

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Keywords

Colorectal cancer
 
discusses
 
pivotal phase III trials
 
renal cell carcinoma
 
review summarizes target antigens
 
therapeutic vaccines
 
vaccine approaches
 
vaccine development
 
vaccine strategies
 
Vaccines
 

Katherine Kabaker