Cytoreductive nephrectomy in the elderly: A population-based cohort from the USA

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada.
BJU International (Impact Factor: 3.53). 09/2011; 109(12):1807-12. DOI: 10.1111/j.1464-410X.2011.10569.x
Source: PubMed


Study Type – Therapy (cohort)
Level of Evidence 2b
What's known on the subject? and What does the study add?
While cytoreductive nephrectomy is associated with a survival benefit in the context of metastatic renal cell carcinoma, the rates of morbidity and perioperative mortality remain non-negligible. For example, perioperative mortality may be as high as 21% in elderly patients.
The study shows that perioperative death amongst the elderly was substantially lower than what was previously reported from a single institutional report. Nonetheless, postoperative adverse outcomes were non-negligible in elderly patients relative to their younger counterparts. In consequence, these rates should be discussed at informed consent and a rigorous patient selection remains essential.

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