Article

Peli1 (rel)ieves autoimmunity.

Institute of Immunology, National University of Ireland Maynooth, Maynooth, Ireland.
Nature Immunology (impact factor: 26.01). 01/2011; 12(10):927-9. DOI:10.1038/ni.2108 pp.927-9
Source: PubMed

ABSTRACT T cell tolerance is essential to the prevention of autoimmunity. The ubiquitin E3 ligase Peli1 acts as a negative regulator of T cell activation and contributes to the maintenance of self-tolerance.

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Keywords

autoimmunity
 
negative regulator
 
self-tolerance
 
T cell activation
 
T cell tolerance
 
ubiquitin E3 ligase Peli1 acts