Urinary glycosaminoglycans in horse osteoarthritis. Effects of chondroitin sulfate and glucosamine

Departamento de Clínica Médica, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, USP, São Paulo, SP, Brazil.
Research in Veterinary Science (Impact Factor: 1.41). 09/2011; 93(1):88-96. DOI: 10.1016/j.rvsc.2011.08.009
Source: PubMed


Our objectives were to characterize the urinary excretion of glycosaminoglycans (GAGs) in horse osteoarthritis, and to investigate the effects of chondroitin sulfate (CS) and glucosamine (GlcN) upon the disease. Urinary GAGs were measured in 47 athletic horses, 20 healthy and 27 with osteoarthritis. The effects of CS and GlcN were investigated in mild osteoarthritis. In comparison to normal, urinary GAGs were increased in osteoarthritis, including mild osteoarthritis affecting only one joint. Treatment with CS+GlcN led to a long lasting increase in the urinary CS and keratan sulfate (KS), and significant improvement in flexion test of tarsocrural and metacarpophalangeal joints was observed. In conclusion, urinary CS and KS seems to reflect the turnover rates of cartilage matrix proteoglycans, and the measurement of these compounds could provide objective means of evaluating and monitoring joint diseases.

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Available from: Raquel Y A Baccarin, Apr 22, 2015
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    • "This disease is mainly characterized by primary degeneration of the articular cartilage and may affect one or several joints at the same time, affecting both young and adult animals (Weaver 1997). DJD is highly prevalent in humans (Brooks 2002) and in animals, especially in dogs (Biasi et al. 2005) and horses (Frisbie et al. 2008, Baccarin et al. 2012). DJD is also commonly reported in cattle (Persson et al. 2007, Heinola et al. 2013), but to date, descriptions of DJD in buffaloes and mini cattle have not been found in the literature. "
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