Article

Y-autosome translocation interferes with meiotic sex inactivation and expression of autosomal genes: a case study in the pig.

Laboratoire de Génétique Cellulaire, UMR 444, Institut National de la Recherche Agronomique, Université de Toulouse, Toulouse, France.
Sexual Development (impact factor: 2.27). 09/2011; 6(1-3):143-50. DOI:10.1159/000331477 pp.143-50
Source: PubMed

ABSTRACT Y-autosome translocations are rare in humans and pigs. In both species, these rearrangements can be responsible for meiotic arrest and subsequent infertility. Chromosome pairing abnormalities on the SSCX, SSCY and SSC1 chromatin domains were identified by analyzing pachytene spermatocytes from a boar carrying a (Y;1) translocation by immunolocalization of specific meiotic protein combined with FISH. Disturbance of the meiotic sex chromosome inactivation (MSCI) was observed by Cot-RNA-FISH and analysis of ZFY gene expression by sequential RNA- and DNA-FISH on spermatocytes. We hypothesized that the meiotic arrest observed in this boar might be due to the silencing of critical autosomal genes and/or the reactivation of some sex chromosome genes.

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Keywords

Chromosome pairing abnormalities
 
Cot-RNA-FISH
 
critical autosomal genes
 
DNA-FISH
 
immunolocalization
 
meiotic arrest
 
meiotic sex chromosome inactivation
 
sex chromosome genes
 
specific meiotic protein
 
SSC1 chromatin domains
 
SSCX
 
subsequent infertility
 
Y-autosome translocations
 
ZFY gene expression
 

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