Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats.
ABSTRACT Sustained hyperglycemia is considered as a major cause of sexual and erectile dysfunction in human population. Curculigo orchioides (CO) is considered as a sexual tonic in Ayurvedic system of medicine with potent antioxidant and adaptogenic properties. The aqueous extract of the herb was evaluated for its effectiveness against streptozotocin-induced hyperglycemic stress and subsequent sexual dysfunction due to hyperglycemia in male rats. Six groups with eight male rats in each group were used for this study and the study was carried out for 28 days. The body and organ weights of the animals were recorded. Behavioral analysis of rats was undertaken to observe the effect on mount, ejaculation and intromission (latencies and frequencies) and hesitation time. Blood glucose and serum testosterone levels were determined 28 days past treatment with CO at 100 and 200 mg kg(-1) doses. Glibenclamide and sildenafil citrate were used as positive controls. This deleterious effect of sustained hyperglycemia and associated stress was prominently ameliorated in animals treated with aqueous extract of CO. CO treatment was helpful in ameliorating the damage caused by sustained hyperglycemia evidenced in the principle parameters viz. male sexual behavior, sperm count, penile erection index and seminal fructose content Antioxidant and anabolic activities of the extract under investigation could be a major attribute in preserving the sexual functions in hyperglycemic male rats. The study validates the use of CO in traditional medicine for curing diabetes-induced sexual dysfunction and compromised sexual potency.
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ABSTRACT: The history of sexual medicine and management of male sexual dysfunction (MSD) is as old as human civilization. The modern life styles and environmental conditions have increased prevalence of MSD with age. To address this problem a number of therapeutic strategies including the use of medicinal plants have been advocated for management of MSD. Large numbers of research papers regarding aphrodisiac activity of medicinal plants have been published in past few years. This review compiles data on the potential aphrodisiac activity of medicinal plants possessing effective dose of less than equal to 200 mg/kgbw or equivalent. The toxicity studies and phytochemical data available for the active extract or active plant part have also been incorporated in this review. Data regarding plant part, dose, animal model, compounds isolated and mechanism of aphrodiasic activity was tabulated. Medicinal plants possess an untapped source of aphrodisiac molecules. The review identified that Bryonia laciniosa, Caesalpinia benthamiana, Ferula harmonis, Montanoa tementosa, Syzygium aromaticum, Turnera aphrodisiaca, Spilanthes acmella, Turnera aphrodisiaca, Turnera diffusa, and Tribulus terrestris plants possess potential aphrodisiac activity. The safety in long term usage and low cost may be added advantage associated with use of herbal aphrodisiacs.
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ABSTRACT: Today diabetes mellitus has emerged as a major healthcare problem throughout the world. It has recently broken the age barrier and has been diagnosed in younger people also. Sustained hyperglycemia is associated with many complications including male reproductive dysfunctions and infertility. Numerous medicinal plants have been used for the management of the diabetes mellitus in various traditional system of medicine and in folklore worldwide as they are a rich source of bioactive phytoconstituents, which lower blood glucose level and/or also act as antioxidants resulting in the amelioration of oxidative-stress-induced diabetic complications. The present review describes the ameliorative effects of medicinal plants or their products, especially on male reproductive dysfunctions, in experimental diabetic animal models.Pharmacognosy Reviews 07/2014; 8(16):113-21. DOI:10.4103/0973-7847.134245
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ABSTRACT: The use of plant or plant-based products to stimulate sexual desire and to enhance performance and enjoyment is almost as old as the human race itself. The present paper reviews the active, natural principles, and crude extracts of plants, which have been useful in sexual disorders, have potential for improving sexual behaviour and performance, and are helpful in spermatogenesis and reproduction. Review of refereed journals and scientific literature available in electronic databases and traditional literature available in India was extensively performed. The work reviews correlation of the evidence with traditional claims, elucidation, and evaluation of a plausible concept governing the usage of plants as aphrodisiac in total. Phytoconstituents with known structures have been classified in appropriate chemical groups and the active crude extracts have been tabulated. Data on their pharmacological activity, mechanism of action, and toxicity are reported. The present review provides an overview of the herbs and their active molecule with claims for improvement of sexual behaviour. A number of herbal drugs have been validated for their effect on sexual behavior and fertility and can therefore serve as basis for the identification of new chemical leads useful in sexual and erectile dysfunction.BioMed Research International 08/2014; 2014:868062. DOI:10.1155/2014/868062 · 2.71 Impact Factor