Regulated functional alternative splicing in Drosophila

Université Montpellier 2, UMR 5535, Institut de Génétique Moléculaire de Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier cedex 05, France.
Nucleic Acids Research (Impact Factor: 9.11). 09/2011; 40(1):1-10. DOI: 10.1093/nar/gkr648
Source: PubMed

ABSTRACT Alternative splicing expands the coding capacity of metazoan genes, and it was largely genetic studies in the fruit-fly Drosophila melanogaster that established the principle that regulated alternative splicing results in tissue- and stage-specific protein isoforms with different functions in development. Alternative splicing is particularly prominent in germ cells, muscle and the central nervous system where it modulates the expression of various proteins including cell-surface molecules and transcription factors. Studies in flies have given us numerous insights into alternative splicing in terms of upstream regulation, the exquisite diversity of their forms and the key differential cellular functions of alternatively spliced gene products. The current inundation of transcriptome sequencing data from Drosophila provides an unprecedented opportunity to gain a comprehensive view of alternative splicing.

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Available from: Jamal Tazi, Jul 28, 2015
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    • "This makes Drosophila particularly well-suited to modeling and studying muscular disorders (García-López et al., 2008; Lloyd and Taylor, 2010; Mosqueira et al., 2010; Timmerman and Sanyal, 2012). Regarding alternative splicing, although important functional conservation occurs between Drosophila and mammals (Venables et al., 2012), dissimilarities have also been described (Mount et al., 1992; Irion, 2012). Results obtained here from the DM1 spliceosensor flies suggested, in this specific condition, that there were only slight alternative splicing machinery differences, hence, still allowing for robust disease mirroring. "
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