Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo.
ABSTRACT Neuromedin B (NMB), a member of the mammalian bombesin-like peptide family, and its receptor were aberrantly expressed in vascularized solid tumors. Here, the NMB receptor (NMB-R) antagonist PD168368 specifically inhibited both NMB-induced in vivo and in vitro angiogenesis. In addition, PD168368 showed growth inhibitory effects on MDA-MB-231 breast cancer cells by inducing cell cycle arrest and apoptosis. Furthermore, PD168368 effectively suppressed tumor growth in a xenograft model of breast tumor in vivo. Overall, NMB-R antagonist exhibited a significant antitumor activity by simultaneously inhibiting neovascularization and cancer cell growth, thereby suggesting that NMB-R could be a potential therapeutic target for cancer treatment.
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ABSTRACT: The pediatric nurse practitioner can use music therapeutically in a variety of clinical situations. Literature supports the effectiveness of music in reducing anxiety based on psychologic and physiological outcomes. Music also enhances standard therapeutic modalities and increases patient satisfaction. Specific interventions should be based on the child's stage be based on the child's stage of development.Journal of Pediatric Health Care 01/1996; 10(2):74-81. · 1.76 Impact Factor