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[Prevention of posterior capsule opacification in experimental studies].

Agnieszka Łukaszewska-Smyk, Józef Kałuzny

Z Kliniki Chorób Oczu Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu.

Journal Article: Klinika oczna 01/2011; 113(4-6):175-9.

Abstract

The pharmaceuticals inhibiting proliferation of epithelium cells or causing their death were tested in experimental studies on PCO prevention. The following antymetabolites were tested: 5-fluorouracil, dounomycin, methotrexat and colchicine, epithelial antibodies against epithelial cells, toxins, hyperosmolar agents and heparin, indomethacine and lignocaine. Moreover, gene therapy with the use of apoptose genes was applied. None of the attempts to prevent PCO was useful for effective and safe clinical treatment.

Source: PubMed

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Keywords

5-fluorouracil
 
apoptose genes
 
colchicine
 
epithelial antibodies
 
epithelial cells
 
epithelium cells
 
experimental studies
 
following antymetabolites
 
gene therapy
 
heparin
 
hyperosmolar agents
 
PCO
 
PCO prevention
 
safe clinical treatment