[The role of disorders of the prooxidant-antioxidant system in diabetes etiopathology].

Małgorzata Mrowicka

Zakład Chemii i Biochemii Klinicznej, Uniwersytet Medyczny w Łodzi.

Journal Article: Postępy Higieny i Medycyny Doświadczalnej (Advances in Hygiene and Experimental Medicine) 01/2011; 65:534-41.

Abstract

Chronic hyperglycemia is believed to play a pivotal role in the development of diabetic complications. It was found that hyperglycemia triggered a number of mechanisms that evoke overproduction of reactive oxygen species (ROS). Diabetes mellitus is associated with an increased level of free radicals, disturbances of the enzymatic antioxidant defense system and lower concentration of exogenous antioxidants. In consequence, these abnormalities lead to a redox imbalance called oxidative stress. The aim of the present study is to summarize the role of reactive oxygen species and changes in the antioxidant defense system in the development of diabetic complications.

Source: PubMed

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Keywords

abnormalities lead
 
antioxidant defense system
 
Chronic hyperglycemia
 
Diabetes mellitus
 
enzymatic antioxidant defense system
 
exogenous antioxidants
 
free radicals
 
increased level
 
lower concentration
 
oxidative stress
 
pivotal role
 
reactive oxygen species
 
ROS