Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.

Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA.
AIDS research and human retroviruses (Impact Factor: 2.46). 09/2011; 28(5):527-30. DOI: 10.1089/AID.2011.0177
Source: PubMed

ABSTRACT A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.

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