Article

Hot-topic debate on kidney function: renal-sparing approaches are ineffective.

Division of Gastroenterology and Hepatology, University of Minnesota, Minneapolis, MN 55455, USA.
Liver Transplantation (impact factor: 3.39). 08/2011; 17 Suppl 3:S50-3. DOI:10.1002/lt.22429 pp.S50-3
Source: PubMed

ABSTRACT Key Points: 1. Both acute kidney injury and chronic renal disease are common in patients undergoing liver transplantation. The etiologies are mixed. 2. The incidence of chronic renal failure after liver transplantation is unacceptable, and it has a significant impact on long-term outcomes after liver transplantation. 3. The role of calcineurin inhibitors (CNIs) in the development of posttransplant chronic renal failure is likely overrated. 4. The use of CNIs in the early posttransplant period is currently essential. 5. Whether new agents will be able to provide effective immunosuppression as primary immunosuppressives remains to be proven.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

calcineurin inhibitors
 
chronic renal disease
 
chronic renal failure
 
CNIs
 
Key Points
 
liver transplantation
 
new agents
 
patients undergoing liver transplantation
 
posttransplant chronic renal failure
 
posttransplant period
 
primary immunosuppressives
 
significant impact
 

John R Lake